Reviewed by Virginia Chachati MPharm
(2013, University College London)
GPhC Registration number: 2087654
Information last reviewed 25/06/2021
Aciclovir is an antiviral medicine used to treat infections caused by the herpes virus. It is commonly prescribed to treat genital herpes, cold sores, chickenpox and shingles. Aciclovir does not cure viral infections. It helps sores to heal, reduces itching and eases pain. Aciclovir can prevent infections in people who have a weak immune system due to medical conditions or the medicines they take.
The two most common infections caused by the herpes virus are cold sores and genital herpes. While symptoms usually clear up, the virus stays in your skin for the rest of your life. You may experience random outbreaks of cold sores or genital herpes. People who have more than 6 outbreaks in a year can take aciclovir for 6 to 12 months as a preventative, or see a specialist for advice.
Aciclovir does not cure genital herpes or cold sores. Cold sores can take up to 10 days to heal, and aciclovir stops them from spreading or getting worse.
Dose |
200mg, 5 times per day |
Type of Medicine |
Antiviral |
Mechanism |
Competitively inhibits and inactivates viral DNA processes, preventing replication |
Available Size |
15, 30, 45 or 168 tablets |
Available Strengths |
400mg |
Active Ingredient |
Aciclovir |
Price |
From 21p per tablet |
Side Effects |
Can include nausea, vomiting, diarrhoea, headaches, stomach pains, feeling dizzy, feeling tired, fever, itching, skin rash |
The active ingredient in aciclovir tablets is aciclovir.
The inactive ingredients in aciclovir tablets are colloidal anhydrous silica, magnesium stearate, povidone, sodium starch glycollate, indigo carmine lake (E132), microcrystalline cellulose (E460)
Please Note: Different brands of generic aciclovir may contain different inactive ingredients. Please read the patient information leaflet provided for more details
You should take aciclovir tablets by mouth as prescribed by your doctor. To treat cold sores and genital herpes, take 1 tablet 5 times a day and leave 4 hours between each dose. To prevent cold sores and genital herpes, take 1 tablet 4 times a day and leave 6 hours between each dose for 6 to 12 months.
If you have a weak immune system, take 1 tablet 4 times a day with 6 hours between each dose. If you have a problem with your kidney function, you should take 1 tablet twice a day and leave 12 hours between each dose.
Aciclovir tablets are available in 400 mg tablets from Dr Felix. If you cannot swallow tablets, you can dissolve the tablets in water and then drink the liquid mixture.
Aciclovir tablets are available as 400 mg tablets from Dr Felix. Your doctor will prescribe the right dose for you and advise you on how to take it.
When you take aciclovir, you might get side effects. Common side effects (affecting less than 1 in 10 people) include dizziness and headaches, nausea or vomiting, diarrhoea, stomach pain, skin rashes and itching, tiredness, sensitivity to sunlight or artificial lights or a high temperature.
Uncommon side effects (which occur in less than 1 in 100 people) include pale or red raised patches on the skin, severe itching and hair loss.
Less than 1 in 1000 people who take aciclovir might get the following rare side effects:
Extremely rare side effects, which affect less than 1 in 10,000 people, can include:
Speak to your doctor immediately if you experience signs of anaphylaxis (severe allergic reaction) when taking this medicine. Signs include swelling of the face and lips, tongue or throat, and difficulty breathing or swallowing.
You should not take aciclovir if you are allergic to aciclovir or any of the other ingredients in aciclovir tablets. You should speak to your doctor and take extra care when taking aciclovir if you have nervous system problems or kidney problems. You need to drink plenty of water whilst taking aciclovir, especially if you are elderly or taking doses of higher than 4 g per day.
Speak to your doctor if you are taking or have been taking any other medicines including:
If you are pregnant, breastfeeding or trying for a baby, you should speak to your doctor before using aciclovir tablets. Your doctor might recommend using aciclovir cream instead.
Aciclovir is available as tablets or cream. Aciclovir cream is available over the counter and helps treat cold sores. You should apply aciclovir cream on your cold sore five times per day for few days. Do not put aciclovir cream inside the vagina, eyes or mouth.
Aciclovir tablets are used to treat herpes infections that cannot be treated with aciclovir cream. This includes genital herpes. Aciclovir tablets help prevent frequent outbreaks and reduce the spread of viral infections in those with a weak immune system.
Yes, dispersible aciclovir is available from Dr Felix. If you cannot swallow aciclovir tablets, they can be dispersed or dissolved in a glass of water. To do this, mix one 400 mg tablet in at least 100 ml of water and swallow all the liquid to get your full dose.
For mild cases of herpes infection, aciclovir cream can be bought over the counter without a prescription. Aciclovir cream will help treat most cases of cold sores, but you should speak to your doctor if you get cold sores regularly. You can use aciclovir cream and these tips help to clear up your cold sores:
Yes, you can still be contagious whilst taking aciclovir. The herpes simplex virus is contagious from the first signs of a new outbreak, right up until the sores have fully healed, even when taking aciclovir. It is important to avoid passing on the virus while you have symptoms. If you have a cold sore you should avoid kissing others, especially babies.
Aciclovir is not an addictive medicine. If you accidentally take more aciclovir than recommended, contact a doctor immediately. Overdosing on this medicine can affect your stomach and intestines, or your nervous system.
Aciclovir is not an antibiotic. Aciclovir is an antiviral and treats infections caused by a virus. Antibiotics are used to treat bacterial infections and cannot be used to treat viral infections.
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