Buy Buccastem online to help ease the nausea associated with migraines

  • Treats nausea and vomiting caused by migraines
  • Contains prochlorperazine
  • Available from £17.99 + prescription fees and delivery costs

Our prices

Strength Quantity Price Stock
3mg8 tablets£17.99Out of Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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Virginia Chachati

Reviewed by Virginia Chachati MPharm
(2013, University College London)
GPhC Registration number: 2087654

Information last reviewed 08/02/21


What is Buccastem?

Buccastem is a tablet that dissolves in your mouth and helps treat nausea and vomiting caused by migraines.

How does Buccastem work?

Buccastem contains the antiemetic medicine prochlorperazine. It works by blocking the dopamine receptors in the vomiting centre of the brain. This stops the nerves from communicating feelings of nausea, preventing the vomiting reflex from being triggered.

Buccastem summary


1 or 2 tablets twice a day for no longer than 2 days

Type of Medicine Phenothiazine antipsychotic for nausea

Blocks certain dopamine receptors, preventing the triggering of the vomiting reflex

Available Size

8 tablets

Available Strengths


Active Ingredient

Prochlorperazine maleate


From £2.25 per tablet

Side Effects

Can include jaundice, blood problems, absence of menstrual periods, breast tenderness and swelling (in men as well as women), milk secreting from the breasts not due to breastfeeding, feelings of restlessness and anxiety


Active ingredients

The active ingredient in Buccastem is prochlorperazine.

Inactive ingredients

The other ingredients in Buccastem are compressible sugar (sucrose), povidone K30, xanthan gum, locust bean gum, talc, magnesium stearate and riboflavin sodium phosphate.


How to take Buccastem

Buccastem should not be swallowed or chewed. To use Buccastem, place the tablet underneath your upper lip alongside your gum. The tablet will soften and stick to the gum. It dissolves slowly, and the medicine will be absorbed through your gum into your bloodstream. Do not touch or move the tablet around, and do not eat while you have a Buccastem tablet in your mouth.

You should take 1 or 2 tablets twice a day, for a maximum of two days. Always take Buccastem as your doctor or pharmacist has prescribed. 

What should I do if I forget to take Buccastem?

If you forget to take Buccastem, use it as soon as you remember if you still feel nauseous. Do not take double the dose to make up for a missed one.

What should I do if I take too much Buccastem?

If you take too much Buccastem then seek medical attention straight away. Take the packet with you so that the doctor can see what you've taken.

Side Effects

Buccastem side effects

Possible side effects of Buccastem include: 

  • Drowsiness 
  • Dizziness 
  • Dry mouth 
  • Insomnia 
  • Agitation 
  • Skin reactions 
  • Photosensitivity 
  • Low blood pressure 
  • High blood sugar 
  • Cholestasis 
  • Abnormal movements or tremors 
  • Impotence
  • Ejaculation problems 
  • Painful erections 
  • Gum irritation 

Rare side effects of Buccastem may include: 

  • Jaundice 
  • Blood problems 
  • Swollen breasts in men or women 
  • Breast secretion 
  • Lack of menstruation 
  • Restlessness 
  • Anxiety 

 Serious side effects that need immediate medical attention include: 

  • Allergic reaction (swelling around the face, rash and difficulty breathing)
  • High temperature, muscle stiffness, pale complexion and lack of alertness 
  • Convulsions 
  • Infection which may cause headaches, sweating, shivering, high temperature, sore throat, flushing or swollen glands 
  • Blood clots
  • Decreased sodium concentration in the blood


Do not use Buccastem if: 

  • You are allergic to any of the ingredients in the medicine 
  • You are pregnant or breastfeeding 
  • You have liver problems 
  • You have blood problems 
  • You have epilepsy 
  • You have Parkinson's disease 
  • You have glaucoma 
  • You have problems with your prostate gland 
  • You are under 18 years old

 Talk to your doctor before taking Buccastem if any of the following apply to you: 

  • If you are elderly 
  • If you have risk factors for blood clots or strokes 
  • If you have a family history of blood clots 
  • If you have myasthenia gravis 
  • If you have AIDS

 Buccastem can increase your sensitivity to sunlight. So try to use sun protection and avoid direct exposure to the sun while you are using Buccastem.

Drug interactions

Certain medicines may interact with Buccastem. If you are taking any of the following medicines, make sure you tell your doctor: 

  • Sedatives
  • High blood pressure medicines
  • Anticholinergic medicines
  • Anticonvulsants 
  • Lithium 
  • Desferrioxamine 
  • Anticoagulants 
  • Levodopa 

Buccastem and pregnancy

Buccastem should not be used during pregnancy. Speak to your doctor for advice on an alternative.

Buccastem and alcohol

You should not drink alcohol while taking Buccastem.

Buccastem and driving

Buccastem can cause drowsiness so you should not drive or operate machinery after taking it.

Treatment Options

Alternatives to Buccastem

Buccastem is a medicine that helps treat nausea and vomiting. You can use Buccastem alongside painkillers or a different type of migraine treatment. There are other types of antiemetics which work in a similar way to Buccastem. These include: 

  • Domperidone 
  • Metoclopramide 
  • Stemetil

 Like Buccastem, Stemetil also contains prochlorperazine. Stemetil is essentially the same medicine as Buccastem, except it comes in tablet, syrup and injection form instead of dissolving in the mouth.

How to prevent migraines

The best way to prevent a migraine is to identify what is triggering them, and avoid those triggers. Keep a diary to record where and when your migraines take place, the environmental factors that are present, and anything you eat or drink. Try to drink plenty of water to stay hydrated, eat a healthy balanced diet and get enough exercise to stay well.

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