Climesse is a medication used in hormone replacement therapy (HRT) to relieve the symptoms of menopause in women and to prevent osteoporosis in postmenopausal women. It contains estradiol valerate, a naturally occurring form of oestrogen, and norethisterone, a synthetic form of progesterone.
Climesse is a form of combined hormone replacement therapy. As women approach menopause, their ovaries produce less and less oestrogen. Declining oestrogen levels in the blood can cause symptoms such as irregular periods, mood swings, hot flushes and sweats. Climesse contains an oestrogen supplement, estradiol valerate, to moderate falling levels of oestrogen and to relieve the symptoms. Oestrogen also stimulates the growth of the womb lining, which can lead to endometrial cancer if allowed to build up. Climesse also contains norethisterone, a synthetic form of progesterone, to counter oestrogen’s effect on the womb lining and reduce the risk of cancer.
Declining levels of oestrogen in women can also cause a weakening of the bones, known as osteoporosis. Climesse is sometimes used to prevent osteoporosis in postmenopausal women.
When used correctly, Climesse provides effective relief from the symptoms of menopause and significantly reduces the risk of developing osteoporosis. Climesse is a continuous pill, meaning it is taken without a monthly break for a bleed and is, therefore, most effective in postmenopausal women who have not had a period for 12 months.
It can take a few weeks to feel the benefits of taking Climesse and up to three months in some cases. During this time, you may also experience some spotting or breakthrough bleeding. In many cases, short-term use of this medication will be sufficient for controlling the symptoms of menopause, but some women continue to use Climesse for several years. Your continued need for this medication should be reviewed by a doctor at least once a year, and women on any form of HRT should go for regular gynaecological check-ups.
The active ingredients in Climesse tablets are oestradiol valerate and norethisterone.
The inactive ingredients in Climesse tablets are lactose, maize starch, povidone, talc, magnesium stearate, hydroxypropylmethylcellulose and propylene glycol. Colouring in the tablets is E171 and E172.
The normal dosage for Climesse is 1 x 2mg tablet taken at the same time each day.
You should not start Climesse until at least 12 months after your last natural period. If you have previously been taking an alternative hormone replacement therapy medication, you should carry on taking this pill until the end of the monthly pack. Start taking the Climesse tablets the next day WITHOUT leaving a break between pills.
If you have not been taking any alternative hormone replacement therapy, you can start taking Climesse on any day of the month.
You should swallow one 2mg tablet of Climesse at the same time each day. Try and make this a part of your daily routine - for example, you might wish to take your pill with breakfast every day, or when you brush your teeth. When you reach the end of the monthly pack, start the next pack immediately without taking a break between packs.
If you miss a pill, try and take it within the next 12 hours. If 12 hours have already passed, just skip the dose and take the next one at your usual time. You should never double up a dose to compensate for the missed pill.
If you miss a pill, try and take it within the next 12 hours. If 12 hours have already passed, just skip the dose and take the next one at your usual time. You should never double-up a dose to compensate for the missed pill.
As with all medicines, Climesse can cause some side effects. You should stop taking your tablets and tell your doctor immediately if you experience severe headaches or symptoms of jaundice (yellowing of the skin or whites of the eyes). Other side effects may include:
If you are worried about any side effects of Climmesse, consult your doctor for advice.
You should not take Climesse tablets if:
Before taking Climesse, inform your doctor if:
Climesse is unlikely to react with other medicines, as the hormones it includes are designed to supplement your own natural hormones. However, you should tell your doctor about any other medications you are taking, including those bought over the counter without a prescription.
Alcohol should be drunk in moderation and with caution while taking this medication.
There are several different types of hormone replacement therapy available online following a consultation with a Dr Felix doctor. Like Climesse, Elleste Duet and Elleste Duet Conti contain synthetic forms of both oestrogen and progesterone and are suitable for women who have not had a hysterectomy, or who do not have an intrauterine system (IUS), or coil, fitted. Elleste Duet is suitable for women who are still experiencing regular bleeds during the onset of menopause. Tibolone, brand name Livial, is a type of steroid which works by activating the oestrogen and progesterone receptors. It is a selective steroid that carries a slightly lower risk of breast cancer.
Hormone replacement therapies containing oestrogen only are also available but are only suitable for women who have had a hysterectomy or who have an IUS fitted. An IUS will do the job of providing the progesterone needed to counteract the risk of endometrial cancer associated with oestrogen supplements. Oestrogen only therapies can be purchased in tablet form (Premarin, Elleste Solo, Kliovance) or in the form of patches to be worn on the skin (Elleste Solo MX80, Elleste Solo MX40, Evorel).
There are several different types of HRT available for the treatment of menopause, and your doctor will be able to help you decide which is best for you. Like Climesse, Elleste Duet, Elleste Duet Conti and Kliovance contain synthetic forms of both oestrogen and progesterone and are therefore suitable for women who have not had a hysterectomy or do not have an IUS fitted. Elleste Duet is more suited to women who still experience regular periods, while Elleste Duet Conti and Kliovance, like Climesse, does not allow for a monthly bleed and is better suited to women who have not had a period in the last 12 months.
For women who have had a hysterectomy, or who have an IUS fitted, HRTs containing an oestrogen synthetic only are also available. These can be purchased as an oral medication (Premarin, Elleste Solo) or as transdermal patches which are applied to the skin (Elleste Solo MX80, Elleste Solo MX40, Evorel).
Another alternative is Tibolone, brand name Livial, a selective steroid that works by activating oestrogen and progesterone receptors in the body. Livial carries a slightly lower risk of breast cancer than other HRTs.
HRT is widely regarded as the best treatment for the symptoms of menopause and is easily accessible online from Dr Felix. Some women may choose to try herbal supplements as an alternative means of relieving their symptoms, although the effectiveness of such treatments is unknown. Make sure to speak to a doctor or pharmacist about the effects of different herbal supplements before trying them.
Menopause can be made more bearable with a few simple lifestyle changes. Increasing your intake of vitamin D, which is essential for the absorption of calcium, will help to keep your bones strong, and exercising regularly will improve your general health and help to relieve stress. Discomfort caused by vaginal dryness can be managed by purchasing moisturisers and lubricants from any pharmacy, and your pharmacist will be able to choose which is best for you. To lessen the impact of hot flushes and night sweats, try cutting down on caffeine, alcohol and spicy foods, and if you smoke, try and quit. Even if you are using HRT, these measures will help you feel the benefits and contribute to your overall wellbeing.
If you vomit soon after taking your Climesse pill, it is unlikely that it will have had time to be absorbed into your system. If you feel well enough, try and take your pill within the next 12 hours. If not, just skip the dose and take your next pill at the normal time.
Climesse is not bioidentical because it contains norethisterone, which is a synthetic rather than naturally occurring form of progesterone.
Cyclical HRT tablets
Cyclical HRT tablets
Continuous combined HRT tablets
Cyclical HRT tablets
Continuous combined HRT tablets
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