If menopausal symptoms trouble you, Climesse might be the right treatment

Climesse is an HRT pill that contains synthetic variants of progestogen and oestrogen for treating the typical symptoms of the menopause. 

Climesse has been discontinued. Alternative therapies include Elleste Duet Conti or Kliovance.

Our prices

Strength Quantity Price Stock
2mg84 tablets£59.99Out of Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

Safe and discreet

  • Safe and regulated treatments
  • 100% discreet and confidential
  • UK qualified doctors
  • Fully registered UK pharmacy


Dr Samantha Miller

Reviewed by Dr Samantha Miller MB ChB
(2017, University of Glasgow)
GMC number: 7561464

Information last reviewed 27/05/2021


What is Climesse?

Climesse is a medication used in hormone replacement therapy (HRT) to relieve the symptoms of menopause in women and to prevent osteoporosis in postmenopausal women. It contains estradiol valerate, a naturally occurring form of oestrogen, and norethisterone, a synthetic form of progesterone.

How does Climesse work?

Climesse is a form of combined hormone replacement therapy. As women approach menopause, their ovaries produce less and less oestrogen. Declining oestrogen levels in the blood can cause symptoms such as irregular periods, mood swings, hot flushes and sweats. Climesse contains an oestrogen supplement, estradiol valerate, to moderate falling levels of oestrogen and to relieve the symptoms. Oestrogen also stimulates the growth of the womb lining, which can lead to endometrial cancer if allowed to build up. Climesse also contains norethisterone, a synthetic form of progesterone, to counter oestrogen’s effect on the womb lining and reduce the risk of cancer.

Declining levels of oestrogen in women can also cause a weakening of the bones, known as osteoporosis. Climesse is sometimes used to prevent osteoporosis in postmenopausal women.

How effective is Climesse?

When used correctly, Climesse provides effective relief from the symptoms of menopause and significantly reduces the risk of developing osteoporosis. Climesse is a continuous pill, meaning it is taken without a monthly break for a bleed and is, therefore, most effective in postmenopausal women who have not had a period for 12 months.

When does Climesse start to work?

It can take a few weeks to feel the benefits of taking Climesse and up to three months in some cases. During this time, you may also experience some spotting or breakthrough bleeding. In many cases, short-term use of this medication will be sufficient for controlling the symptoms of menopause, but some women continue to use Climesse for several years. Your continued need for this medication should be reviewed by a doctor at least once a year, and women on any form of HRT should go for regular gynaecological check-ups.


Active ingredients

The active ingredients in Climesse tablets are oestradiol valerate and norethisterone.

Inactive ingredients

The inactive ingredients in Climesse tablets are lactose, maize starch, povidone, talc, magnesium stearate, hydroxypropylmethylcellulose and propylene glycol. Colouring in the tablets is E171 and E172.


Climesse dosage

The normal dosage for Climesse is 1 x 2mg tablet taken at the same time each day.

How to start Climesse?

You should not start Climesse until at least 12 months after your last natural period. If you have previously been taking an alternative hormone replacement therapy medication, you should carry on taking this pill until the end of the monthly pack. Start taking the Climesse tablets the next day WITHOUT leaving a break between pills.

If you have not been taking any alternative hormone replacement therapy, you can start taking Climesse on any day of the month.

How to take Climesse?

You should swallow one 2mg tablet of Climesse at the same time each day. Try and make this a part of your daily routine - for example, you might wish to take your pill with breakfast every day, or when you brush your teeth. When you reach the end of the monthly pack, start the next pack immediately without taking a break between packs. 

What should I do if I took a pill too late?

If you miss a pill, try and take it within the next 12 hours. If 12 hours have already passed, just skip the dose and take the next one at your usual time. You should never double up a dose to compensate for the missed pill.

What should I do if I missed a pill?

If you miss a pill, try and take it within the next 12 hours. If 12 hours have already passed, just skip the dose and take the next one at your usual time. You should never double-up a dose to compensate for the missed pill.

Side Effects

Climesse side effects

As with all medicines, Climesse can cause some side effects. You should stop taking your tablets and tell your doctor immediately if you experience severe headaches or symptoms of jaundice (yellowing of the skin or whites of the eyes). Other side effects may include:

  • Breast tenderness or enlargement
  • Weight gain
  • Wind, stomach pains or bloated feeling
  • Stomach pains, nausea or sickness
  • Dizziness or irritability
  • Skin rash
  • Increase in vaginal fluid
  • High blood pressure or palpitations
  • Headaches or muscle cramps
  • Change in sexual desire
  • Spots
  • Feeling tired or depressed

If you are worried about any side effects of Climmesse, consult your doctor for advice.


You should not take Climesse tablets if:

  • You are pregnant, think you might be pregnant or are breastfeeding.
  • You have ever had breast cancer or any lumps in your breast not considered by a medical professional to be harmless.
  • You have or might have any type of cancer that is sensitive to hormones.
  • You are experiencing unusual vaginal bleeding.
  • You have thrombosis (problems with circulation) or embolism (blood clotting too easily). Characteristics are red sores over your veins, or pains in your chest and legs when you walk.
  • You have severe heart, liver or kidney problems.
  • You are allergic to any of the ingredients in Cilmesse

Before taking Climesse, inform your doctor if:

  • You have gallstones or mild liver disease.
  • You have or have had jaundice, Dubin-Johnson syndrome or Rotor syndrome.
  • You have porphyria.
  • You have hearing loss due to otosclerosis.
  • You experience migraines or are epileptic.
  • You have cysts or nodules in your breast.
  • You have problems with your womb, such as endometriosis or fibroids.
  • You have multiple sclerosis.
  • You have diabetes
  • You have systemic lupus erythematosus.
  • You have hypertension (high blood pressure)

Drug interactions

Climesse is unlikely to react with other medicines, as the hormones it includes are designed to supplement your own natural hormones. However, you should tell your doctor about any other medications you are taking, including those bought over the counter without a prescription.

Climesse and alcohol

Alcohol should be drunk in moderation and with caution while taking this medication.

Treatment Options

Alternatives to Climesse

There are several different types of hormone replacement therapy available online following a consultation with a Dr Felix doctor. Like Climesse, Elleste Duet and Elleste Duet Conti contain synthetic forms of both oestrogen and progesterone and are suitable for women who have not had a hysterectomy, or who do not have an intrauterine system (IUS), or coil, fitted. Elleste Duet is suitable for women who are still experiencing regular bleeds during the onset of menopause. Tibolone, brand name Livial, is a type of steroid which works by activating the oestrogen and progesterone receptors. It is a selective steroid that carries a slightly lower risk of breast cancer. 

Hormone replacement therapies containing oestrogen only are also available but are only suitable for women who have had a hysterectomy or who have an IUS fitted. An IUS will do the job of providing the progesterone needed to counteract the risk of endometrial cancer associated with oestrogen supplements. Oestrogen only therapies can be purchased in tablet form (Premarin, Elleste Solo, Kliovance) or in the form of patches to be worn on the skin (Elleste Solo MX80, Elleste Solo MX40, Evorel).

Climesse vs other forms of HRT

There are several different types of HRT available for the treatment of menopause, and your doctor will be able to help you decide which is best for you. Like Climesse, Elleste Duet, Elleste Duet Conti and Kliovance contain synthetic forms of both oestrogen and progesterone and are therefore suitable for women who have not had a hysterectomy or do not have an IUS fitted. Elleste Duet is more suited to women who still experience regular periods, while Elleste Duet Conti and Kliovance, like Climesse, does not allow for a monthly bleed and is better suited to women who have not had a period in the last 12 months.
For women who have had a hysterectomy, or who have an IUS fitted, HRTs containing an oestrogen synthetic only are also available. These can be purchased as an oral medication (Premarin, Elleste Solo) or as transdermal patches which are applied to the skin (Elleste Solo MX80, Elleste Solo MX40, Evorel).

Another alternative is Tibolone, brand name Livial, a selective steroid that works by activating oestrogen and progesterone receptors in the body. Livial carries a slightly lower risk of breast cancer than other HRTs.

Alternatives to HRT

HRT is widely regarded as the best treatment for the symptoms of menopause and is easily accessible online from Dr Felix. Some women may choose to try herbal supplements as an alternative means of relieving their symptoms, although the effectiveness of such treatments is unknown. Make sure to speak to a doctor or pharmacist about the effects of different herbal supplements before trying them.

Lifestyle changes to improve menopause symptoms

Menopause can be made more bearable with a few simple lifestyle changes. Increasing your intake of vitamin D, which is essential for the absorption of calcium, will help to keep your bones strong, and exercising regularly will improve your general health and help to relieve stress. Discomfort caused by vaginal dryness can be managed by purchasing moisturisers and lubricants from any pharmacy, and your pharmacist will be able to choose which is best for you. To lessen the impact of hot flushes and night sweats, try cutting down on caffeine, alcohol and spicy foods, and if you smoke, try and quit. Even if you are using HRT, these measures will help you feel the benefits and contribute to your overall wellbeing.


If I have vomited, will Climesse still work?

If you vomit soon after taking your Climesse pill, it is unlikely that it will have had time to be absorbed into your system. If you feel well enough, try and take your pill within the next 12 hours. If not, just skip the dose and take your next pill at the normal time. 

Is Climesse bioidentical?

Climesse is not bioidentical because it contains norethisterone, which is a synthetic rather than naturally occurring form of progesterone.

Prices from:

Start your consultation now

We’re a fully regulated pharmacy, with qualified doctors and happy customers


Quick and discreet

A good honest company I've been with them for a couple of years absolutely no complaints. Just praise

Mrs Winter

What is your gender?

  • Male
  • Female

Quick and discreet

Straightforward & efficient service. Easy to use & gives me peace of mind. Would thoroughly recommend. Thank you.