Order Colofac 135mg & 200mg tablets online to treat IBS

Colofac (Mebeverine is the generic name) is an antispasmodic medication that can alleviate the symptoms of irritable bowel syndrome (IBS).

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Strength Quantity Price Stock
135mg100 tablets£15.99In Stock
135mg200 tablets£26.99In Stock
200mg60 capsules£12.99In Stock
200mg120 capsules£20.99In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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What is Colofac?

Colofac is a brand name for the drug Mebeverine, which is used to alleviate the symptoms of irritable bowel syndrome (IBS). While the exact cause of IBS is not always known, it is often related to abnormal muscle contraction or inflammation in the intestine. This can be triggered by stress, hormones or even some foods, and common symptoms of IBS include stomach cramps, bloating, diarrhoea or constipation.

How does Colofac work?

Colofac contains mebeverine hydrochloride, a type of medicine known as an antispasmodic. It works by relaxing the muscle wall of the intestine, preventing irregular muscle spasms and relieving symptoms such as cramps, bloating, diarrhoea and constipation.

How long does Colofac take to work?

Most people who suffer with IBS experience regular flare ups rather than constant symptoms. Unless otherwise advised by a doctor, it is best to take Colofac when needed (during a flare up) rather than all the time. For best results, take one tablet about 20 minutes before a meal, but no more than 3 times per day. Colofac aims to clear up the symptoms of IBS within 2 weeks. If your symptoms continue for longer than 2 weeks, speak to your doctor for advice. 


Active ingredients

The active ingredient in Colofac is mebeverine hydrochloride.

Inactive ingredients

The inactive ingredients of Colofac are lactose, starch, povidone, talc, magnesium stearate, sucrose, gelatin, acacia and carnauba wax.


Colofac dosage

The recommended dose is 1 tablet 3 times a day before meals.

How to take Colofac

Swallow one Colofac tablet with water about 20 minutes before a meal, no more than 3 times per day. If symptoms improve, you can lower your dose to 2 or 1 tablet/s per day. This medication should be used when needed (during a flare up of IBS) and, unless otherwise instructed by a doctor, not all the time. If symptoms do not improve after 2 weeks of taking this medication, speak to your doctor for advice. 

Side Effects

Colofac side effects

Side effects of this medication are rare. However, if you are taking Colofac and experience a severe allergic reaction (swelling of the face, neck, tongue or throat and/or difficulty breathing) stop taking the medication and contact a doctor at once. Less serious side effects can include a skin rash or red itchy skin. Speak to a doctor or pharmacist if you are concerned about these side effects.


Do NOT start taking Colofac if you are allergic to any of the ingredients listed above. This medicine is not normally recommended for use in children under the age of 10.

You should consult your doctor before taking Colofac if:

  • You have not previously suffered from IBS
  • Your symptoms have worsened or you have developed new symptoms
  • You have kidney or liver problems

Speak to a doctor or pharmacist before taking Colofac if:

  • You are over 40 years of age and your symptoms have changed, or you have not experienced IBS in some time
  • You notice blood in your stools
  • You are experiencing nausea or vomiting
  • You look pale or feel tired
  • You feel constipated
  • You have a fever
  • You have recently travelled abroad
  • You are pregnant or planning on becoming pregnant
  • You experience unusual vaginal bleeding or discharge (women)
  • You experience difficulty or pain when passing urine

Drug interactions

There are no known interactions of Colofac with other medicines.

Colofac and alcohol

It is safe to drink alcohol while taking this medication.

Colofac and pregnancy

Little is known about the risks of taking Colofac while pregnant. Speak to your doctor for advice if you are pregnant or planning on becoming pregnant before taking this medication.

Treatment Options

Alternatives to Colofac

The active ingredient in Colofac, mebeverine hydrochloride, is also available in the form of dispersible sachets sold under the name Fybogel Mebeverine. This medication also includes the active ingredient ispaghula husk, which is a natural prebiotic that promotes the growth of healthy probiotics in the gut and a mild laxative. Colpermin capsules contain peppermint oil, which acts as a natural spasmodic, and are an effective alternative to Colofac. It is of note that Colpermin capsules also contain peanut oil and are therefore unsuitable for use in patients with a peanut allergy.


What can Colofac be used to treat?

Colofac is used to treat IBS in adults and children over 10 years of age. In special cases, it may sometimes be used to treat intestinal spasms in children younger than 10 years of age.

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