Differin Gel

Differin is a prescription only medicine sold in the UK for acne. Order Differin cream online by filling in a simple questionnaire for our GPs to review and issue an online prescription.

You can also buy Differin gel from our online acne clinic however Differin cream is recommended for people with sensitive skin since it is absorbed better.

Start your 2 minute consultation

Our prices

Strength Quantity Price
0.1% strength1 tube£24.95
0.1% strength2 tubes£47.95
Prices exclude a prescription fee. Find out more

Safe and discreet

  • Safe and regulated treatments
  • 100% discreet and confidential
  • UK qualified doctors
  • Fully registered UK pharmacy


About Differin

Differin comes in cream or gel form and is used to reduce inflammation and soreness of the skin caused by acne. Acne is a skin condition which is likely to affect everyone at some point in their lives. It is characterised by spots on the face, back and chest which can either be smaller blackheads, whiteheads, papules or pustules, or more severe nodules or cysts. These spots and inflammation arise when bacteria grows in a blocked hair follicle containing trapped sebum (oil). There are a variety of possible causes of acne, including; hormones, diet, vitamin deficiency, stress and genetics. Acne can have a negative impact on confidence and cause distress or anxiety in individuals suffering from this condition. Differin cream treats the symptoms of acne on the surface of the skin by clearing blocked pores and decreasing the swelling and inflammation.

What is the difference between Differin cream and gel?

Differin cream and gel both contain 0.1% of the same active ingredient, although the cream is absorbed more quickly and easily and is therefore more suitable for sensitive skin.

Does Differin prevent acne?

Differin can prevent new outbreaks as it clears blogged pores which lead to spots.

Where can Differin be used?

Differin can be used on the face, chest or back where acne is present.

Can I use other acne products with Differin?

Other acne products (containing benzoyl peroxide, erythromycin or clindamycin) can be used with Differin, although they must be used in the morning as Differin is applied at night.


  • Do not apply Differin to areas of skin which have cuts, grazes, eczema or sunburn. Avoid contact with the eyes, mouth, angle of the nose or any other sensitive areas of skin.
  • Differin can increase the skin’s sensitivity to UV light; therefore you should avoid exposure to strong sunlight and artificial UV light. It is recommended to cover the treated area with protective clothing and use sunscreen on exposed skin.
  • Differin should not be used if you are pregnant although it can be used if you are breastfeeding. During breastfeeding, avoid applying Differin to the chest area.
  • Do not use Differin if you are allergic to adapalene or any of the other ingredients contained.


Differin cream contains the active ingredient adapalene which has an anti-inflammatory effect on the skin.

Differin gel contains the active ingredient adapalene which has an anti-inflammatory effect on the skin.


Apply a thin film of Differin gel / cream to the affected area once daily and rub in gently.

Differin should be applied at night before going to bed unless otherwise directed by your doctor. Ensure the skin is clean and dry before applying Differin gel or cream. Wash your hands after using Differin gel.

Side Effects

Differin cream or gel are both only absorbed into the body in small amounts and its main effect is on the surface of the skin.

Common side effects of using Differin cream or Differin gel include:

  • Dry skin
  • Skin irritation
  • Burning sensation of the skin
  • Redness of the skin

Uncommon side effects of using Differin cream include:

  • Skin reaction
  • Skin discomfort
  • Sunburn
  • Itching of the skin
  • Skin peeling
  • Acne flare up


You can learn more about the condition here – Acne – Diagnosis, Causes and Treatment

Prices from:

Start your consultation now

We’re a fully regulated pharmacy, with qualified doctors and happy customers


Quick and discreet

Amazing service will definitely be using again!!


What is your gender?

  • Male
  • Female

Quick and discreet

This is my second purchase and it’s always easy and quick to get what you need - will continue to use