Elleste Duet Conti

Order Elleste Duet Conti to ease your menopause effects

Elleste Duet Conti is a form of HRT that effectively reduces menopause symptoms. It contains norethisterone and estradiol — forms of the female hormones progesterone and oestrogen.

Our prices

Strength Quantity Price Stock
2mg/1mg84 tablets£37.99In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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Dr Samantha Miller

Reviewed by Dr Samantha Miller MB ChB
(2017, University of Glasgow)
GMC number: 7561464

Information last reviewed 04/06/2021


What is Elleste Duet Conti?

Elleste Duet Conti is a form of hormone replacement therapy (HRT). It contains two hormones: oestrogen (estradiol hemihydrate) and progestogen (norethisterone acetate). It is a form of HRT used in women who have not had a period for at least 1 year. It is used to relieve menopausal symptoms.

How does Elleste Duet Conti work?

Elleste Duet Conti is a form of hormone replacement therapy (HRT). It contains two hormones: oestrogen (estradiol hemihydrate) and progestogen (norethisterone acetate). It is a form of HRT used in women who have not had a period for at least one year, to alleviate menopausal symptoms such as hot flushes, night sweats and mood changes. Elleste Duet Conti is also licenced for the prevention of osteoporosis in postmenopausal women under certain circumstances. 

The estradiol component effectively supplements your own body’s declining oestrogen levels, which is the root cause of menopausal symptoms. The progestogen component protects your endometrium (womb lining) from becoming excessively thickened due to the action of oestrogen. 


Active ingredients

The active ingredients in each Elleste Duet Conti tablet are 2mg estradiol and 1mg norethisterone.

Inactive ingredients

The other ingredients are lactose monohydrate, maize starch, povidone 25, talc, magnesium stearate, hydroxypropylmethylcellulose (E464), titanium dioxide (E171), macrogol 400 and black iron oxide (E172).


How do I take Elleste Duet Conti tablets?

The medication should be taken as directed by your doctor or pharmacist. 

If you are not taking any other form of HRT, you can start taking Elleste Duet Conti right away. Take one tablet each day at a time most suited to you. However, it is recommended that you take the medication at the same time every day. Make sure to swallow the tablet whole and do not break it up. The medication strip comes with the days marked to help you remember to take them every day. Once you finish the strip, start the next strip the following day. 

If you’re new to HRT, you can start Elleste Duet Conti at any time. If you’re changing from a continuous sequential or cyclical HRT which normally results in a monthly bleed, it’s best to complete your current pack or cycle, and start Elleste Duet Conti the next day, without a break in therapy. However, if you’re switching from another type of continuous combined HRT and don’t usually experience any bleeding, you’re free to switch at any time. 

What if I miss a dose of Elleste Duet Conti?

If you miss a dose, take the tablet as soon as you remember. For the next dose, take it at the normal time. If the tablet is missed by more than 12 hours, dispose of that tablet and take the next dose at the normal time. Never take two doses together to make up for a forgotten dose.

What if I take more than recommended?

If you take more than is recommended by accident, it’s important to speak with your doctor as soon as possible. Minor overdose is rarely harmful but may lead to breast tenderness, nausea or vomiting, irregular periods, feeling down and tired, the development of acne or increased growth of body hair and facial hair.

Side Effects

Elleste Duet Conti side effects

Very common side effects occurring in more than 1 in 10 women:

  • Headache
  • Breast pain or tenderness
  • Changes in vaginal bleeding including painful menstruation or irregular bleeding. 

Common side effects may affect 1 in 10 women:

  • Feeling down or depressed
  • Feeling anxious or nervous
  • Mood changes
  • Changes in sex drive
  • Feeling dizzy
  • Difficulty sleeping
  • Feeling sick
  • Bloating
  • Diarrhoea
  • Indigestion
  • Abdominal pain
  • Acne
  • Rashes 
  • Itchiness
  • Dry skin
  • Back pain
  • Pain in the extremities
  • Breast enlargement
  • Heavy periods
  • Vaginal discharge
  • Break-through bleeding
  • Spasms (contractions) of the womb
  • Vaginal infection including thrush
  • Excessive thickening of the lining of the womb
  • Feeling of weakness
  • Swelling of the ankles
  • Feet and fingers
  • Weight gain

Uncommon symptoms may affect 1 in 100 people:

  • Migraines
  • Vertigo 
  • High blood pressure
  • Varicose veins
  • Vomiting
  • Gallstones and gallbladder disease
  • Change in colour of the skin
  • Muscle cramps
  • Breast cancer 
  • Changes in liver function tests
  • Rare symptoms may affect 1 in 1,000 people:


  • Tingling or numbness
  • A blood clot in a vein
  • Inflammation of a vein
  • Muscle weakness
  • Growths in the womb (myoma, cysts, polyps).
  • Very rare symptoms may affect 1 in 10,000 people:
  • Increase in body and facial hair
  • Yellowing of the skin


If any of the following criteria apply, you should not use Elleste Duet Conti:

  • Known or suspected breast cancer or a past history of breast cancer
  • Known or suspected cancer in which growth of the cancer is stimulated by oestrogen, for example, endometrial cancer 
  • Untreated overgrowth of the lining of the womb known as endometrial hyperplasia.
  • Vaginal bleeding of an unknown cause
  • Any blood disorders that increase the risk of blood clots in the veins
  • A blood clot in a vein of the leg (deep vein thrombosis) or a blood clot in the lungs (pulmonary embolism)
  • Recently suffered from a stroke 
  • Recently experienced a heart attack
  • Angina pectoris
  • Active liver disease or a history of liver disease when liver function has not returned to normal
  • Porphyria
  • Pregnant or breastfeeding

You should speak to your doctor if you have or unsure if you have any of these conditions as this medication is not suitable for you. 

Speak to your doctor also if you have any of the following as you may still be able to take Elleste Duet Conti, but with closer supervision:

  • Uterine fibroids
  • Risk factors for thrombosis e.g. obesity, major surgery, postpartum, cancer)
  • Risk factors for hormone-sensitive cancers e.g. a strong family history of breast or ovarian cancer
  • Hypertension
  • Liver disorders
  • Diabetes
  • Gallstones
  • Migraines
  • Systemic lupus erythematosus (SLE)
  • A history of endometrial hyperplasia
  • Epilepsy
  • Asthma
  • Otosclerosis (an ear condition)


Does Elleste Duet Conti cause hair loss?

Elleste Duet Conti does not generally cause hair loss, and the frequency of hair loss cannot be estimated from current data. Hirsutism (excess growth of facial and body hair) is a very rare side effect, occurring in 1 in 10,000 people.

Does Elleste Duet Conti cause bleeding?

Elleste Duet Conti does not cause regular monthly bleeding and is designed to be taken by women who have finished their periods. However, in the first few months of taking the medication, it might cause spotting or breakthrough bleeding. If you miss a dose of the medication, this might increase the risk of breakthrough bleeding. If this breakthrough bleeding is still occurring after the first few months of treatment, or after stopping the treatment, it is best to consult your doctor for advice. 

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