Epiduo Gel

Epiduo Gel offers an effective and reliable acne treatment

Epiduo Gel is an acne treatment gel that contains two active ingredients: adapalene and benzoyl peroxide. Epiduo Gel quickly helps reduce skin redness and swelling associated with acne.

Our prices

Strength Quantity Price Stock
0.1%/2.5%1 x 45 g tube£29.70In Stock
0.1%/2.5%2 x 45g tubes£59.80In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

Safe and discreet

  • Safe and regulated treatments
  • 100% discreet and confidential
  • UK qualified doctors
  • Fully registered UK pharmacy


Virginia Chachati

Reviewed by Virginia Chachati MPharm
(2013, University College London)
GPhC Registration number: 2087654

Information last reviewed 24/04/21


What is Epiduo Gel?

Epiduo Gel is an acne treatment you can apply straight onto your skin. Epiduo Gel contains two active ingredients: adapalene and benzoyl peroxide.

How does Epiduo Gel work?

Epiduo Gel works in two ways to combat acne. Adapalene is a type of retinoid which reduces inflammation and prevents the cells that carry acne bacteria from multiplying. Benzoyl peroxide works by decreasing the amount of bacteria which cause acne. It also dries out the skin, causing it to peel. Together, the ingredients both treat acne spots and prevent new ones from breaking out.

How long does Epiduo Gel take to work?

Epiduo Gel starts working after a few weeks of daily application. It normally takes a couple of months for Epiduo Gel to clear acne completely.

Is Epiduo Gel an antibiotic? 

Epiduo Gel is not an antibiotic. It contains a combination of two active ingredients: a retinoid (adapalene) and an antimicrobial peeling agent (benzoyl peroxide). These ingredients encourage new skin cell growth and prevent bacteria from causing acne.

Where can I use Epiduo Gel?

Epiduo Gel is typically used to treat acne on the face, back and chest. Your doctor may recommend that you use it on other parts of your body, if required, for treatment.

Is Epiduo Gel suitable for severe acne?

While Epiduo Gel is effective at treating mild to moderate acne, severe acne usually requires oral antibiotics or a stronger retinoid, like isotretinoin, to treat it. However, once severe acne has started to clear, your doctor may recommend Epiduo Gel as the acne becomes milder and requires lower concentrations of medicine to treat it.

What causes acne?

Acne occurs when the pores in your skin become blocked with dead skin cells and excess oil, known as sebum, from the sebaceous glands. Bacteria can get trapped and multiply inside these pores which results in spots or pustules forming. The main cause of acne is when hormonal changes take place, for example during puberty and menstruation. Genetics can also be a factor. Acne commonly affects teenagers but can occur in adults at any age.


How to use Epiduo Gel?

Epiduo Gel should be applied to clean, dry skin once a day before bedtime. With clean hands, apply a thin layer of Epiduo Gel to the affected skin area. Make sure to wash your hands thoroughly afterwards. Keep your hair and clothing away from the area you have applied Epiduo Gel as it can cause staining.

How long should I use Epiduo Gel for?

Always use Epiduo Gel as your doctor or pharmacist has prescribed. It's likely that you will need to use it for a couple of months until your acne completely clears. In the first couple of weeks, your acne may look like it’s getting worse. This is due to Epiduo Gel working on spots underneath your skin. After this, you should start to notice a visible improvement.

What should I do if I forget to use Epiduo Gel?

If you forget to use Epiduo Gel at night, do not apply it the following morning. Wait until bedtime to apply your next dose. Epiduo Gel can make your skin more sensitive to sunlight so you must not apply it during the day. You can try setting an alarm or reminder on your phone or calendar so you don’t forget to apply Epiduo Gel at night.

What should I do if I use too much Epiduo Gel?

Using more Epiduo Gel than you need can cause skin irritation, dryness and redness. If you use too much Epiduo Gel, you should stop applying it to the irritated area until your skin fully recovers. Applying extra Epiduo Gel won't help your acne disappear any faster and may make your symptoms worse.

Side Effects

Possible side effects of Epiduo Gel include: 

  • Irritated skin 
  • A burning sensation where the gel has been applied
  • Dry skin 
  • Irritative contact dermatitis 
  • Redness 
  • Scaling 
  • Itchy skin 
  • Sunburn 

Signs of an allergic reaction include: 

  • Tightness in the throat
  • Swelling in the face, lips, tongue or eyes 
  • Feeling faint 
  • Having trouble breathing 
  • Hives 

If you experience any of these allergic reaction symptoms stop using Epiduo Gel and seek immediate emergency medical attention.


Do not use Epiduo Gel if you are allergic to any of the ingredients. 

Epiduo Gel should not be used on areas of the skin affected by: 

  • Cuts 
  • Scrapes 
  • Sunburn 
  • Eczema 
  • Broken skin 

Avoid too much exposure to sunlight or UV rays while using Epiduo Gel and do not apply it close to your eyes, mouth or nostrils.

You must not use Epiduo Gel if you are pregnant or planning a pregnancy.

Drug Interactions

Do not use any other acne treatments containing benzoyl peroxide or retinoids, similar to adapalene, alongside Epiduo Gel. You should also avoid using cosmetics or products which can irritate, dry out or exfoliate your skin.

Is Epiduo Gel safe to use during pregnancy?

Epiduo Gel should not be used during pregnancy or if you are planning a pregnancy. If you become pregnant while you are using Epiduo Gel, tell your doctor and stop using it straight away.

Can I use Epiduo Gel if I'm breastfeeding?

You can use Epiduo Gel while you are breastfeeding. Do not apply Epiduo Gel around the chest or breast area so your baby does not come into contact with the treatment.

Treatment Options

Alternatives to Epiduo Gel

There are many options to treat acne. What works best for you will depend on the severity of your symptoms. Over the counter creams, gels or washes contain benzoyl peroxide and can work well if you only have a few spots. Prescription treatments your doctor may recommend for moderate to severe acne include: 

  • Topical retinoids 
  • Topical antibiotics 
  • Oral antibiotics 
  • Azelaic acid 
  • Combined oral contraceptive pill 
  • Oral isotretinoin

What's the difference between Epiduo Gel and other acne creams?

Epiduo Gel differs from other acne creams or gels as it is a combination treatment. It contains two active ingredients to help treat acne; benzoyl peroxide, an antimicrobial peeling agent, and adapalene, a retinoid.

How can I manage acne at home?

There are steps you can take to help manage acne at home. These include: 

  • Cleanse your face twice a day 
  • Avoid over-washing 
  • Avoid squeezing or picking spots as this can cause permanent scarring or skin pigmentation
  • Use makeup that is non-comedogenic and doesn't clog up your pores 
  • Shower as soon as possible after exercising 
  • Wash hair regularly as hair oils can transfer to your skin 
  • Applying a hydrocolloid plaster over the spot to help skin heal
  • Drinking plenty of water to help with skin recovery

Using toothpaste to dry out spots is not recommended as it can irritate your skin.

How can I treat acne naturally?

There are natural remedies that can work well for mild spots and pimples. These include: 

  • Tea tree oil 
  • Antibacterial high UMF grade manuka honey 
  • Witch hazel

Does Epiduo Gel work for acne scars?

Epiduo Gel will not get rid of old, deep acne scars but it will help prevent new scars from forming.


Can I still wear makeup while using Epiduo Gel?

You can wear makeup while using Epiduo Gel. Non-comedogenic cosmetics are recommended so they do not clog up your pores. However, you should not apply makeup directly on top of Epiduo Gel on your skin at night.

Why do I have acne as an adult?

Adult acne is common and can affect anyone. The main reasons for acne occurring in adulthood are hormonal imbalances or hormonal changes. These include menstruation, pregnancy and menopause. Sometimes adult acne can be genetic or occur as a side effect after using certain medicines.

Can I buy Epiduo Gel over the counter?

Epiduo Gel is only available on prescription and cannot be purchased over-the-counter. We provide an online prescription for the treatment after a free consultation with one of our doctors.


Active ingredients

The active ingredients in Epiduo Gel are Adapalene and Benzoyl peroxide. 

Inactive ingredients

The inactive ingredients in Epiduo Gel are docusate sodium, disodium edetate, glycerol, poloxamer, propylene glycol (E1520), Simulgel 600 PHA and purified water.

Which ingredients can cause an allergic reaction?


A very serious allergic reaction to this gel medication is rare. It is imperative you seek emergency medical attention if you experience any of these serious symptoms, including a rash, itching or swelling of the face or tongue, severe dizziness, or difficulty breathing. You should also stop using the medication if you notice any of these symptoms and let your prescribing doctor know. 

Start your consultation now

We’re a fully regulated pharmacy, with qualified doctors and happy customers


Quick and discreet

I ordered Azithromycin tablets for chlamydia treatment, received it next day in a brown discreet pack, and cheaper than all other pharmacies, can't ask for more

Jordan McCann

What is your gender?


Cheaper than the rest

Cheaper than other pharmacies, received the medicine fast and in discreet packaging as promised. Will use again.