Order Esomeprazole (generic Nexium) to treat acid reflux

Esomeprazole works by decreasing the amount of acid in your stomach, which relieves symptoms like heartburn and GORD. Reducing acid production also allows stomach ulcers and oesophageal damage to heal.

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Strength Quantity Price Stock
20 mg28 tablets£22.49In Stock
20 mg56 tablets£42.00In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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What is Esomeprazole?

Esomeprazole is a medication used to treat acid reflux, heartburn and gastro-oesophageal reflux disease (GORD). It's a type of medicine known as a proton pump inhibitor.

How does Esomeprazole work?

Esomeprazole works by decreasing the amount of acid in your stomach to relieve symptoms like heartburn, a persistent cough and having difficulty swallowing. Esomeprazole blocks the enzymes which line the stomach wall that normally produce acid, reducing acid reflux and allowing the stomach to heal.

How long does Esomeprazole take to work?

Esomeprazole will start to have an effect after 2-3 days of taking it. It can take up to 4 weeks for the medicine to work fully so it's possible to experience reduced symptoms until then.

Is Esomeprazole safe for long term use?

Taking Esomeprazole long term can increase your risk of experiencing side effects. After three months this can include:

  • Tiredness
  • Dizziness
  • Confusion
  • Muscle twitches
  • Shaking
  • Irregular heartbeat
  • Potential side effects after one year of taking Esomeprazole include:
  • Bone fractures
  • Infections of the gut
  • Vitamin B12 deficiency

You should see your doctor on a regular basis if you have taken Esomeprazole for longer than a year.

Can Esomeprazole cause stomach cancer?

A study in Hong Kong attempted to find a link between proton pump inhibitors and stomach cancer but the results only indicated an association. Advice from the NHS states that the risk is very small and that the conclusions drawn from the study didn't prove that these medications cause the risk.

Are acid reflux and heartburn the same thing?

Heartburn is a symptom of acid reflux, causing an unpleasant burning sensation in the middle of the chest. It's fairly common and is usually caused by consuming certain types of food and drink, pregnancy, smoking and stress. Other symptoms of acid reflux include:

  • An unpleasant taste
  • Coughing
  • Persistent hiccups
  • Hoarse voice
  • Bad breath
  • Bloating
  • Nausea


Active ingredients

The active ingredient in Esomeprazole is esomeprazole magnesium dihydrate.

Inactive ingredients

The inactive ingredients in the medicine are Methacrylic acid-ethyl acrylate copolymer (1:1), talc, triethyl citrate, hypromellose, sugar spheres, magnesium stearate, hydroxypropyl cellulose, glycerol monostearate 40-55, polysorbate 80, microcrystalline cellulose, povidone, macrogol 6000, crospovidone, sodium stearyl fumarate.



The dose prescribed will depend on what you are being treated for.

  • If you have heartburn and damage to your gullet (food pipe) the dose will be 40mg once daily for 4 weeks, reducing to 20mg a day
  • If you have heartburn with no gullet damage the standard dose is 20mg per day.
  • If you have a stomach ulcer caused by the Helicobacter pylori bacteria the dose is 20mg twice daily in combination with antibiotics
  • If you have a stomach ulcer caused by anti-inflammatory drugs the dose will be 20mg once a day for 4-8 weeks

How to take Esomeprazole

Always take Esomeprazole as your doctor or pharmacist has prescribed. The instructions may vary depending on why you are taking it and the severity of your symptoms. The medication is usually taken once a day with or without food. They should be taken with a glass water and can be dissolved in water if you are unable to swallow tablets.

Can you dissolve Esomeprazole in water?

You can dissolve Esomeprazole tablets in water if you have difficulty swallowing pills. Ensure you don't snap them in half or crush them as that will compromise the tablet coating. Instead, place the tablet in half a glass of water and stir it gently until it dissolves, drinking it straight away.

How long should I take Esomeprazole for?

How long you should take Esomeprazole will depend on why you are taking it. For minor instances of heartburn and acid reflux it's likely you'll take Esomeprazole for 1-2 weeks. To treat stomach ulcers you may need to take it for up to 8 weeks. After the initial symptoms or infection has been treated, you can then use Esomeprazole as needed when heartburn and acid reflux symptoms occur.

What should I do if I forget to take Esomeprazole?

If you forget to take your scheduled dose of Esomeprazole, take it as soon as you can. If you normally take it once a day and it's less than 12 hours until your next dose is due then skip the missed one. If you are on a twice daily dose then skip the missed one if it is less than four hours until you are due to take the next one.

What should I do if I take too much Esomeprazole?

Taking an extra dose of Esomeprazole by accident is unlikely to cause any issues. If you experience any of the following symptoms however then report this to your doctor:

  • Sweating
  • Fast heartbeat
  • Sleepiness
  • Confusion or agitation
  • Blurred vision

What food or drink should I avoid while taking Esomeprazole?

Food and drink will not interfere with Esomeprazole but it's recommended to avoid foods which are known to trigger acid reflux. These include spicy and fatty foods, chocolate, coffee, tea, alcohol and fizzy drinks.

How do I come off Esomeprazole?

In most cases you can stop taking Esomeprazole after your treatment period without any adverse effects. If you have been taking the medication for a long period of time, consult your doctor first. They may instruct you to gradually reduce the dose to prevent your stomach from producing excess acid.

Side Effects

Side Effects

Common side effects include:

  • Headaches
  • Diarrhoea
  • Stomach pain
  • Flatulence
  • Constipation
  • Nausea
  • Vomiting
  • Benign polyps in the stomach

Less common side effects may include:

  • Swollen ankles or feet
  • Insomnia
  • Dizziness
  • Pins and needles
  • Sleepiness
  • Vertigo
  • Dry mouth
  • Changes in blood tests which determine liver function
  • Rash
  • Hives
  • Itchy skin
  • Hip, wrist or spine fractures after long term use of high doses

Rare side effects can include:

  • A reduced number of white blood cells
  • A reduced level of sodium in the blood
  • Agitation or confusion
  • Depression
  • Altered taste
  • Blurred vision
  • Wheezing and feeling short of breath
  • Mouth inflammation
  • Thrush of the gut
  • Hair loss
  • Skin sensitivity to sunlight
  • Muscle or joint pain
  • Increased sweating
  • Feeling generally unwell and lacking in energy

The following side effects are signs of an allergic reaction which requires immediate medical assistance:

  • Sudden wheezing
  • Swollen lips, tongue or throat
  • Rash
  • Fainting
  • Having difficulty swallowing
  • Jaundice


Esomeprazole should not be taken if:

  • You are allergic to any other proton pump inhibitors
  • You are taking any medicines which contain Nelfinavir
  • You are a child under 12

Consult a doctor before using Esomeprazole if:

  • You have severe liver problems
  • You have severe kidney problems
  • You have ever experienced a skin reaction with similar medicines that treat excess stomach acid
  • You are scheduled to have a blood test

If you experience any of the following symptoms while you are taking Esomeprazole report this to a doctor right away:

  • Sudden, unexplained weight loss
  • Problems swallowing
  • Stomach pain or indigestion
  • Vomiting or vomiting blood
  • Passing black stools

This could indicate other conditions or illnesses which are being masked by Esomeprazole.

How to cope with Esomeprazole side effects

Ensure you are drinking plenty of water while taking Esomeprazole to avoid Headaches and dehydration from diarrhoea. Painkillers are suitable to take alongside Esomeprazole if needed. If you experience nausea or vomiting, take it after food and avoid eating anything spicy or rich. Introducing high fibre foods into your diet can help to relieve constipation and avoiding lentils, beans, onions and overeating should ease stomach pain and wind.

Drug Interactions

Always let you doctor or pharmacist know about any additional medications you are taking, or planning to take. This includes herbal remedies and over the counter treatments.

Esomeprazole is not suitable for individuals taking medicine which contains Nelfinavir to treat HIV.

If you are taking any of the following medications inform your doctor before taking Esomeprazole:

  • Atazanavir
  • Saquinavor
  • Clopidogrel
  • Ketoconazole
  • Itraconazole
  • Voriconazole
  • Erlotinib
  • Citalopram
  • Imipramine
  • Clomipramine
  • Diazepam
  • Phenytoin
  • Blood thinners
  • Cilostazol
  • Cisapride
  • Digoxin
  • Methotrexate
  • Tacrolimus
  • Rifampicin

Treatment Options

Alternatives to Esomeprazole

Alternatives to Esomeprazole include Lansoprazole, Omeprazole, Pantoprazole and Rabeprazole. These are all proton pump inhibitors and work in the same way as Esomeprazole.

Can I take Esomeprazole with antacids?

You can take Antacids such as Gaviscon alongside Esomeprazole. Ensure you leave at least two hours between each medicine.

Can I take Esomeprazole with painkillers?

It is safe to take painkillers at the same time as Esomeprazole. If you plan to take ibuprofen, it's recommended to do so either with or after food to avoid a stomach upset.

Can Lifestyle changes help?

There are some lifestyle changes you can make to reduce acid reflux and heartburn. These include:

  • Consuming small, frequent meals
  • Adjust your bed so that your head and chest are propped up higher than your waist
  • Maintain a healthy weight
  • Find ways to effectively manage stress  

Avoid consuming foods which will trigger heartburn or eating too close to bedtime. Cut down on alcohol and stop smoking and try not to wear tight clothing which cling to the waist.

What causes acid reflux?

There is not always a definite reason why you are experiencing heartburn and acid reflux but common causes include:

  • Certain types of food and drink including coffee, chocolate, alcohol, spicy and fatty foods
  • Smoking
  • Pregnancy
  • Stress
  • Anxiety
  • Being overweight
  • Certain types of medication
  • A hiatus hernia

What foods cause acid reflux?

Foods which are known to trigger acid reflux and cause heartburn include:

  • Meat
  • Dairy
  • High fat foods and oils
  • Chocolate
  • Mint
  • Citrus fruits
  • Coffee
  • Tea
  • Alcohol, particularly wine and beer  
  • Onions

What are ways to manage acid reflux?

There are several things you can do to reduce acid reflux and prevent symptoms from being triggered. Wait at least 2-3 hours after eating before you go to bed, eating five small meals instead of three large ones per day and chew slowly. Avoiding heartburn triggers and taking medication like Esomeprazole also help.

How can you stop acid reflux?

Esomeprazole stops acid reflux by blocking the production of acid in the stomach to allow it to return to normal. Aside from this, taking care not to overeat, avoiding spicy, fatty foods and not eating before bed can help to stop acid reflux from being triggered. Reducing caffeine and alcohol consumption is also recommended.

Can stress trigger acid reflux?

Stress is a common trigger for symptoms of acid reflux. There are several theories as to why this is. For example when stress hormones increase, this has an impact on lipids called prostaglandins which regulate the body's response to inflammation and injury. When this decreases, it leaves the stomach more sensitive to the effects of acid, increasing the likelihood of symptoms like heartburn. Stress can also cause changes in the body which can lead to acid reflux.


Esomeprazole and alcohol

Drinking alcohol will not interfere with Esomeprazole however it is not recommended to drink during treatment as it can trigger acid reflux and further irritate the lining of your stomach.

Can you get Esomeprazole over the counter?

A brand of Esomeprazole called Nexium is available over-the-counter as a 20mg dose. Check the above guidance to ensure the medication is suitable for you, or consult a pharmacist if you are unsure.

Will Esomeprazole affect my fertility?

Esomeprazole does not have an affect on fertility in either men or women.

Will Esomeprazole affect my contraception?

Esomeprazole does not have an impact on the effectiveness of the Contraceptive pill, however it may interfere with the ellaOne emergency contraceptive pill.

Can I drive while taking Esomeprazole?

It's unlikely that Esomeprazole will affect your ability to drive. However, if you experience dizziness or blurred vision then do not drive or operate heavy machinery.

Esomeprazole and pregnancy

If you are pregnant, or trying for a baby, then consult your doctor before taking Esomeprazole to make sure it is safe for you. Do not take Esomeprazole while breastfeeding as it is not known if the medication passes into breast milk or not.


NHS> Esomeprazole

NHS> Acid Reflux drugs linked to increased stomach cancer risk

NHS> Heartburn and acid reflux

Web MD> What lifestyle changes help manage heartburn?

Health Line> Can stress cause acid reflux?

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