Fluconazole

Clear out thrush fast with Fluconazole oral capsules

Fluconazole 150mg is an effective antifungal medicine that comes in a single dose capsule and typically cures thrush infection in more than 80% of men and women.

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Strength Quantity Price Stock
150mg1 capsule£6.85In Stock
150mg2 capsules£8.15In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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Information

Dr Samantha Miller

Reviewed by Dr Samantha Miller MB ChB
(2017, University of Glasgow)
GMC number: 7561464

Information last reviewed 28/03/2021

About

What is Fluconazole?

Fluconazole is an oral medication that is used to treat yeast infections, commonly known as thrush, caused by the Candida fungus. Fluconazole is used to treat a variety of fungal infections, including vaginal, penile and oral thrush.

How does Fluconazole work?

Fluconazole is an antifungal medicine that works by stopping Candida yeasts from building new cells. So it essentially stops the Candida yeast from being able to multiply and maintain itself in such high numbers. This leads to an overall reduction in the number of yeast cells, and in most cases, complete elimination of the troublesome symptoms.

How effective is Fluconazole?

A single 150mg dose of fluconazole will usually clear up 80–95% of yeast infections. However, it may not work for everyone, so if your symptoms persist or come back soon after being treated, your doctor might need to prescribe additional treatment.

Ingredients

Active ingredient

The active ingredient in this medication is 150mg of fluconazole.

Inactive ingredients

The other ingredients include: lactose monohydrate, microcrystalline cellulose, pregelatinised maize starch, sodium lauryl sulfate, colloidal anhydrous silica, magnesium stearate, titanium dioxide (E171), quinoline yellow (E104), sunset yellow (E110), gelatin

Please note: different brands of fluconazole may contain different inactive ingredients.

Dosage

How to take Fluconazole?

Fluconazole is normally taken as a one-off 150mg capsule which should be swallowed whole with a glass of water. It can be taken at any time of the day, with or without food.

Fluconazole dosage

The first line dosage of fluconazole for uncomplicated thrush is typically a single 150mg capsule, however, the dose you are given will depend on what type of infection you are being treated for. Always take the amount specified by your doctor.

Can Fluconazole be crushed or split?

Fluconazole should be swallowed whole with a glass of water. It should not be crushed or split. If you think you’ll struggle to swallow it, consult your prescriber for advice.

Side Effects

Fluconazole side effects

Common side effects: affect up to 1 in 10 people

  • Stomach upset including discomfort, nausea, vomiting and diarrhoea
  • Headache
  • Rash 

Less common side effects: affect up to 1 in 100 people

  • Indigestion
  • Flatulence (excess wind)
  • Dry mouth
  • Loss of appetite 
  • Altered taste
  • Constipation
  • Anaemia (a reduction in red blood cells) – this can manifest as weakness, breathlessness or pale skin
  • Drowsiness
  • Insomnia (inability to sleep)
  • Seizures
  • Dizziness
  • Sensory changes e.g. numbness or tingling
  • Change in sense of taste
  • Muscle aches
  • Low potassium level – this may manifest as muscle cramps, weakness, nausea or palpitations
  • Increased sweating
  • Feeling weak and tired
  • Fever

Rare side effects: affect up to 1 in 1,000 people

  • Irregular heart rate or rhythm
  • Decreased white blood cells – this may make you more prone to infections
  • Decrease platelets – this might cause bruising or bleeding
  • Hair loss
  • High levels of cholesterol or fats
  • Allergic reaction 

Contraindications

You shouldn't take fluconazole if you: 

  • Have ever experienced an allergic reaction to an antifungal treatment 
  • Are allergic to fluconazole or any of the ingredients included in the medicine 
  • Have porphyria (a rare blood disorder)
  • Are pregnant or breastfeeding

Consult your doctor if you: 

  • Have kidney problems 
  • Have liver problems
  • Have heart failure 
  • Have problems with your heart rate or rhythm
  • Have a reduced amount of electrolytes in your blood
  • Have adrenal insufficiency 
  • Have lactose intolerance or you have a problem metabolising lactose
  • Are under the age of 16 or over 60
  • Have had thrush more than twice in the last 6 months 
  • Have abnormal vaginal bleeding
  • Have vulval sores, ulcers or blisters
  • Have been exposed to a sexually transmitted infection
  • Are experiencing pain or discomfort on passing urine
  • Have lower abdominal pain

Drug interactions

There are certain types of medication that can interact with fluconazole. These include: 

  • Astemizole
  • Cisapride
  • Ergot medicines
  • Pimozide
  • Quinidine
  • Terfenadine
  • Erythromycin
  • Halofantrine

There are many medications that may potentially interact with antifungal medication, so it’s important to disclose all of your regular and recent medication to your prescriber. 

Extra care should be taken if you are taking any of the following: 

  • Blood-thinning medication such as warfarin
  • Amitriptyline
  • Amiodarone
  • Alfentanil
  • Amitriptyline, nortriptyline
  • Benzodiazepines e.g. midazolam
  • Bosentan
  • Bosutinib
  • Bromocriptine
  • Buspirone
  • Cabergoline
  • Calcium channel blockers 
  • Carbamazepine
  • Celecoxib
  • Ciclosporin
  • Cilostazol
  • Colchicine
  • Cyclophosphamide
  • Dapoxetine
  • Darifenacin
  • Dasatinib
  • Disopyramide
  • Domperidone
  • Dronedarone
  • Eliglustat
  • Eplerenone
  • Everolimus
  • Fentanyl
  • Flurbiprofen
  • Halofantrine
  • Ibrutinib
  • Ibuprofen
  • Hydrochlorothiazide
  • Rifampicin

Fluconazole and pregnancy

You should not use fluconazole during pregnancy unless your doctor has specified that it is safe.

Can Fluconazole affect contraception or fertility?

Fluconazole does not impact either your contraception or your fertility. 

Treatment Options

Alternatives to Fluconazole

Fluconazole is an oral antifungal. There are other versions of this type of medication available e.g. itraconazole.

If an oral capsule is not suitable for you, you might wish to use an intravaginal cream or pessary. These are shown to be just as effective for vulvovaginal thrush. 

Fluconazole vs Canesten

Canesten is a brand name of several different products used to treat thrush. Canesten manufactures a 500mg clotrimazole intravaginal pessary, and 10% clotrimazole intravaginal cream 2% clotrimazole cream. Canesten also manufactures handy “combi” packs which include both a pessary or intravaginal cream, and a topical cream to treat both external vulval infection and internal vaginal infection. Intravaginal pessaries or gels are shown to have similar results to oral fluconazole when treating the symptoms of thrush. 

Is Fluconazole available over the counter?

Fluconazole is available to buy over the counter from certain pharmacies, Canesten is the most readily available type of Fluconazole to purchase. 

What if Fluconazole doesn't work for my infection?

Fluconazole will usually start to work after three days and you can expect your symptoms to clear up within seven days. If this doesn't happen, you may need to see your doctor so they can assess your symptoms and rule out other conditions that may be causing them. Aspects of your lifestyle can also leave you prone to yeast infections. Simple tips such as wearing loose-fitting underwear, avoiding perfumed products on your genitals, and keeping blood sugar levels in check can all help to reduce the risk of recurrence.

Q&A

How long does fluconazole take to work?

Symptoms should start to subside within three days of taking fluconazole. If your symptoms persist after a week, you should speak with your doctor.

How long do fluconazole side effects last?

If you experience any side effects of fluconazole, you should speak with your doctor. Most side effects will disappear within 4–5 days.

How long does fluconazole stay in your system?

It will vary depending on your liver and kidney function, but fluconazole may stay in your system for up to 7 days.

Is Fluconazole an antibiotic?

No. Fluconazole is an antifungal treatment, it works to inhibit fungal growth.

Does Fluconazole treat athlete's foot?

Oral fluconazole is not a first-line treatment for athlete's foot. Athlete’s foot is caused by a different type of fungus. Mild cases of athlete's foot respond well to specific topical therapies such as terbinafine cream. More severe cases do require oral therapy, however, fluconazole is not routinely used. If you have athlete's foot, it is recommended that you use a treatment designed for athlete's foot. You should not use medications for conditions that they were not prescribed for unless you have discussed this with your doctor. 

Does Fluconazole help fungal nails?

Fungal nail infections are generally treated with topical therapies. If you have got a fungal nail infection, you should use a treatment designed for this. You should not use treatments that have been prescribed for other purposes without first checking this with your doctor. 

How often can you take Fluconazole?

Fluconazole 150mg is designed to be taken as a one-off dose. If your symptoms clear up but return within 7 days, you may take another capsule. Fluconazole is not designed to be taken on a regular basis, you should contact your doctor if you have persistent symptoms. 

Is Fluconazole a steroid?

Fluconazole is not a steroid, it is an antifungal treatment.

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