Fybogel Mebeverine

Order Fybogel Mebeverine sachets online for IBS

Fybogel Mebeverine is a treatment for Irritable Bowel Syndrome (IBS). It contains mebeverine to help ease painful cramps and ispaghula husk for constipation relief.

Our prices

Strength Quantity Price Stock
135mg/3.5g10 sachets£8.99In Stock
135mg/3.5g20 sachets£13.99In Stock
135mg/3.5g40 sachets£23.99In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

Safe and discreet

  • Safe and regulated treatments
  • 100% discreet and confidential
  • UK qualified doctors
  • Fully registered UK pharmacy


Virginia Chachati

Reviewed by Virginia Chachati MPharm
(2013, University College London)
GPhC Registration number: 2087654

Information last reviewed 02/04/21


What is Fybogel Mebeverine?

Fybogel Mebeverine helps ease the symptoms and discomfort of irritable bowel syndrome (IBS). Each dose comes in a powder form which you mix into a glass of water and swallow.

How does Fybogel Mebeverine work?

Fybogel Mebeverine contains two active ingredients; ispaghula husk and mebeverine. Ispaghula husk is a plant fibre which helps relieve constipation. Mebeverine is an antispasmodic and helps relieve painful cramps.

Can I buy mebeverine on its own?

If you do not want the laxative effect of the ispaghula husk found in Fybogel Mebeverine, you can buy mebeverine on its own to help treat IBS. Mebeverine is available as generic mebeverine 135 mg tablets (brand name Colofac) and generic mebeverine 200mg MR capsules (brand name Colofac MR).

How does mebeverine work?

Mebeverine is a type of medicine called an antispasmodic. Mebeverine works by relaxing the muscles in your intestinal walls. This reduces cramps and relieves pain which are both symptoms associated with IBS.

How long does Fybogel Mebeverine last?

Fybogel Mebeverine is available in packs of 10, 20 or 40 sachets. You can take one sachet twice a day for up to seven days. How long it will last, or the amount of sachets you need to use, will depend on the nature of your symptoms and the prescription from your doctor. If you do not feel better after two weeks, you must speak to your doctor for further advice.

How quickly does Fybogel Mebeverine work?

Fybogel Mebeverine works within 12 to 24 hours after taking it.

How long does mebeverine take to work?

Mebeverine starts to work one hour after taking it as either one mebeverine tablet or one mebeverine MR capsule.


Fybogel Mebeverine dosage

For adults and children over the age of 12 years old, the standard Fybogel Mebeverine dose is one sachet at least 30 minutes before a meal up to twice a day.

How to take Fybogel Mebeverine?

Empty one sachet of Fybogel Mebeverine powder into a glass filled with a minimum of 150 ml of water. Stir until the mixture has dissolved and then drink it immediately. You should drink six to eight glasses of water throughout the day to stay hydrated. Make sure to take your evening dose at least an hour before going to bed to prevent gut irritation.

Can I take Fybogel Mebeverine with other IBS treatments?

You should ask your doctor before taking any additional treatments while taking Fybogel Mebeverine. Generally, Fybogel Mebeverine can be used alongside other IBS treatments such as Buscopan. But if you feel your IBS symptoms are getting worse, you should speak to your doctor for advice.

Side Effects

Mebeverine side effects

You may get a skin rash or red itchy skin after taking mebeverine tablets or mebeverine MR capsules. However, if you feel unwell after taking mebeverine and experience either shortness of breath or swelling around the face, neck, tongue, lips or throat then please seek emergency medical attention as these are signs of a severe allergic reaction.

Fybogel Mebeverine side effects

Side effects you may experience while using Fybogel Mebeverine include: 

  • Bloating
  • Flatulence 
  • Difficulty swallowing 
  • Blockage of the bowel 

You can avoid some of these side effects by taking Fybogel Mebeverine with plenty of water. 

Seek medical attention if you experience: 

  • A rash 
  • Itching 
  • Difficulty breathing
  • Swelling 
  • Hypersensitivity 
  • Eye redness and a runny nose 

These are signs of an allergic reaction to Fybogel Mebeverine. 


You should not use Fybogel Mebeverine if you: 

  • Are allergic to any of the ingredients 
  • Have a blockage of the bowel
  • Have muscle weakness in the bowel
  • Have throat problems or difficulty swallowing 
  • Have constipation which is severe 
  • Have blood in your stools
  • Are breastfeeding 

Consult your doctor if: 

  • You are a care worker and frequently handle medicines that contain ispaghula husk
  • You have phenylketonuria
  • You are over the age of 40 years old
  • You have a debilitating condition 
  • You have abdominal pain
  • You are vomiting
  • You have a fever
  • You are tired and pale
  • You have recently travelled abroad
  • You may be pregnant 
  • You have abnormal vaginal bleeding or discharge 
  • You have acute porphyria
  • You have difficulty urinating 

Drug interactions

Speak to your doctor if you are taking insulin or medicines to treat thyroid problems as your dose of Fybogel Mebeverine may need to be changed. You should not take Fybogel Mebeverine within one hour before or after taking these types of medicines.

Fybogel Mebeverine and pregnancy or breastfeeding

Fybogel Mebeverine is not suitable for use during pregnancy or breastfeeding. Speak to your doctor for further advice.

Treatment Options

Can lifestyle changes help with IBS?

There are lifestyle changes you can make to manage your IBS. Identifying your triggers will help you avoid flare ups. Common triggers include stress, caffeine, alcohol and spicy food. Try drinking plenty of water, ensuring you eat foods high in fibre, maintaining a healthy diet and eating small regular meals.

Alternatives to Fybogel Mebeverine

Fybogel Mebeverine contains an antispasmodic, to ease cramps, and a gentle laxative to help treat IBS. Buscopan, Colofac and Colpermin are alternative antispasmodic treatments to help with cramps or spasms in IBS. Alternative laxatives include senna and bisacodyl, which are stimulants that work overnight for constipation relief. Fybogel (without mebeverine) is also an alternative that is only used to relieve constipation and takes two to three days to work.

Dietary changes to avoid IBS

Keeping a food and wellness diary can help identify which types of food are causing your IBS symptoms to flare up. Avoid spicy foods, caffeine, alcohol and smoking. Try to drink plenty of water and eat high fibre foods with your meals throughout the day.

Can I buy mebeverine over the counter?

You can buy mebeverine over the counter at a pharmacy. It normally comes as a pack of 15 tablets under the brand name Colofac IBS.

Mebeverine and alcohol

You can take mebeverine and drink alcohol at the same time. However, it is not recommended as alcohol can be a trigger for IBS symptoms.

Mebeverine and weight loss

Mebeverine does not directly cause weight loss. If you feel you are losing weight or your IBS symptoms are affecting your eating habits, then please speak to your doctor for advice.

Mebeverine and bloating

Mebeverine can help relieve IBS symptoms such as bloating. You can also help reduce bloating by eating smaller meals, exercising regularly and having less fibre in your diet.


Are women more susceptible to IBS than men?

Almost twice as many women are affected by IBS than men. This could be linked to hormonal changes in women during their menstruation cycle. People may be more likely to suffer from IBS if they are under 45 years old, have mental health problems or if there is a family history of IBS. There are no specific tests to determine whether someone is suffering from IBS.

What can trigger IBS?

IBS can be triggered by certain foods and drinks including: alcohol, fizzy drinks, caffeine, spices, chocolate and processed foods. Psychological factors, such as stress or anxiety, can also trigger IBS.

When will I feel better after taking Fybogel Mebeverine?

Fybogel Mebeverine takes 12 to 24 hours to help you feel better. 

Is long term use of Fybogel Mebeverine safe?

Long term use of Fybogel Mebeverine is only recommended if your doctor has prescribed it. If you have been using Fybogel Mebeverine for two weeks and your symptoms have not improved, then see your doctor for advice. 

Can you take mebeverine long term?

You should only use mebeverine for the duration of time your doctor has prescribed it for. Long term mebeverine use can be recommended for some patients, generally, if they have problems controlling IBS flare ups. Otherwise, mebeverine is only used for short periods of time and whenever you have an IBS flare up.

Will Fybogel Mebeverine help haemorrhoids?

Fybogel Mebeverine should not be used if you are passing blood in your stools, which may be as a result of haemorrhoids. Speak to your doctor for advice if you have haemorrhoids.

Is Fybogel Mebeverine a laxative?

Fybogel Mebeverine contains ispaghula husk, which is a laxative, and can be taken to treat constipation as a result of IBS.

Is it okay to take Fybogel Mebeverine if I have diarrhoea?

Fybogel Mebeverine should not be used if you have diarrhoea.

Should I take Fybogel Mebeverine if I am constipated?

Fybogel Mebeverine contains a laxative which can help relieve constipation due to IBS.

Can I take Fybogel Mebeverine after an operation?

Fybogel Mebeverine should only be used after an operation to relieve constipation if your doctor has prescribed it for you.

What should you do if Fybogel Mebeverine doesn’t work?

If Fybogel Mebeverine doesn't work for you then speak to your doctor, who may recommend an alternative treatment.

Mebeverine or Buscopan?

Mebeverine and Buscopan (hyoscine butylbromide) are both antispasmodics used to treat IBS. However, although Buscopan can start working faster than mebeverine, each dose of mebeverine works for a longer period of time compared to each dose of Buscopan. Mebeverine and Buscopan are both available over the counter in small quantities at a pharmacy.

Can you take mebeverine and Buscopan together?

You should not take mebeverine and Buscopan at the same time. If you feel you need to take mebeverine and Buscopan together, your IBS symptoms may be getting worse and you should see your doctor to discuss your treatment options.


Active ingredients in Fybogel Mebeverine

Fybogel Mebeverine contains the active ingredients ispaghula husk (3.5 g) and mebeverine  hydrochloride (135 mg) in each sachet.

Inactive ingredients in Fybogel Mebeverine

The inactive ingredients in Fybogel Mebeverine are: Potassium hydrogen carbonate, sodium hydrogen carbonate, microcrystalline cellulose, basic butylated methacrylate copolymer, sterilised talc, polyethylene glycol 6000, citric acid, polysorbate 80, silica colloidal anhydrous, saccharin sodium, aspartame E951, orange flavour, beta-carotene, riboflavine sodium phosphate and apo-carotenal colouring.

Active ingredients in mebeverine tablets

Mebeverine tablets contain the active ingredient mebeverine hydrochloride (135 mg).

Inactive ingredients in mebeverine tablets

Mebeverine tablets contain the following inactive ingredients: microcrystalline cellulose, lactose monohydrate, povidone, talc, magnesium stearate, sodium starch glycollate. The tablet coating contains: hydroxypropyl methylcellulose (E464), titanium dioxide (E171) and polyethylene glycol.

Please Note: Different generic brands of mebeverine tablets can contain different ingredients than those listed here. Please read the patient information leaflet provided for further details.

Active ingredients in mebeverine MR capsules

Mebeverine MR capsules contain the active ingredient mebeverine hydrochloride (200 mg).

Inactive ingredients in mebeverine MR capsules

Mebeverine MR capsules contain the following inactive ingredients:
Capsule core: sugar spheres (sucrose, maize), povidone hypromellose. 
Capsule coating: ethyl cellulose N-45, macrogol 6000, magnesium stearate.
Capsule shell: gelatin, titanium dioxide (E171).

Please Note: Different generic brands of mebeverine MR capsules can contain different ingredients than those listed here. Please read the patient information leaflet provided for further details.

Which ingredients can cause an allergic reaction?

As this medication is available in powder form, it is possible to get a skin hypersensitivity reaction if the power comes into contact with the skin. This can present as a rash or hives and if mild can be treated with some antihistamines but make sure to let your doctor know as they might recommend another medication. It is not common to get a severe allergic reaction to this medication but it presents with facial swelling, difficulty breathing and dizziness. If you experience a severe allergic reaction, please get medical attention right away.

Prices from:

Start your consultation now

We’re a fully regulated pharmacy, with qualified doctors and happy customers


Quick and discreet

Made my order and it arrived the next day... Excellent service.


What is your gender?


Quick and discreet

Excellent service all round. Will certainly be using this Company again.