Isotretinoin Gel (Isotrex)

Buy Isotretinoin Gel online (Isotrex) from a UK pharmacy

  • This treatment has been discontinued; other acne treatments are available

  • You can also buy Treclin Gel, which contains tretinoin, a similar retinoid treatment

  • Topical acne treatment that kills acne-causing bacteria, soothes inflammation and reduces redness

Our prices

Strength Quantity Price Stock
0.05%1 x 30g tube£22.49Out of Stock
0.05%2 x 30g tubes£44.99Out of Stock
0.05%3 x 30g tubes£67.49Out of Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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  • Safe and regulated treatments
  • 100% discreet and confidential
  • UK qualified doctors
  • Fully registered UK pharmacy


What is Isotrex?

Isotrex is a topical treatment for acne known as Isotretinoin Gel. It works to reduce the appearance of spots, blackheads and whiteheads and prevents new ones from forming. 

How does Isotrex work

Isotrex contains Isotretinoin which is a type of medicine called a retinoid, a vitamin A derivative. The gel works in three ways: by decreasing the amount of oil produced by the skin, killing acne-causing bacteria and soothing inflammation and redness. 

How long does Isotrex take to work?

Isotrex will begin to take effect after 6-8 weeks of use. The treatment takes time to work and you may notice your symptoms worsening at first. This does not mean that Isotrex isn't working. The Gel penetrates the skin to unclog the pores and push out existing spots to eventually clear your skin and prevent more from arising. 

Does Isotrex cure acne?

Isotrex is effective in clearing mild to moderate acne. You'll need to continue using it for the duration of the treatment as your doctor or pharmacist prescribed otherwise your acne is likely to return. Once you have completed the course of Isotrex, continue to use cleansers and skin products for acne prone skin to keep your complexion clear.

What causes acne?

Acne is defined as having breakouts of spots such as pimples, blackheads and whiteheads. This occurs when the pores in the skin become clogged with excess oils and dead skin cells. Hormonal changes or imbalances are the main cause of this. Acne is often seen as something that occurs during puberty but it commonly affects adults too; bodily processes such as pregnancy and menstruation being contributing factors. Genetics also play a part, if you have a family history of acne then you are more likely to experience it. 

Will Isotrex get rid of cystic acne?

Isotrex is effective for mild to moderate acne with blackheads and whiteheads. Cystic acne is a type of severe acne which causes large oval shaped cysts that are pus-filled. Isotretinoin Gel such as Isotrex is not usually strong enough to treat severe acne. Instead, Isotretinoin tablets will be prescribed. 

Isotretinoin Summary


Thin layer of gel applied over the face once or twice a day

Type of Medicine

Systemic Acne Therapy - Retinoid


Reduces inflammation of the skin, suppresses sebum production, reduces comedogenesis and prevents proliferation of acne-causing bacteria

Active Ingredient


Side Effects

Can include skin tenderness, peeling,dry or itchy skin, burning sensation, altered skin pigmentation, photosensitivity


Active ingredients

Isotretinoin is the active ingredient in Isotex. 

Inactive ingredients

The inactive ingredients are hydroxypropylcellulose, butylated hydroxytoluene (E321) and ethanol.


How to use Isotrex

Isotrex should be applied to clean, dry skin once or twice a day. Apply a thin layer of gel to all areas of the skin affected by acne, washing your hands afterwards. The following precautions should be taken while using Isotrex: 


  • Do not use too much gel 

  • Take care not to use it too close to your mouth, lips and eyes 

  • Do not use it on areas of irritated or sunburnt skin 

  • Use it sparingly on sensitive areas of skin, such as your neck

  • Use additional sun protection and avoid sunbeds for the duration of your treatment

Isotrex contains 0.05% Isotretinoin. The gel should be applied once or twice a day as your doctor has prescribed. 

How long should I use Isotrex for?

Isotrex treatment is prescribed for a period of 4-6 months. When you stop treatment, your skin should continue to improve in the next 8 weeks. If it doesn't, you may need to continue the treatment. 

What should I do if I use too much Isotrex?

Using too much Isotrex can result in red, irritated skin. This will not make your acne disappear any faster. If this occurs, reduce the amount of gel you use for several days. 

What should I do if I forget to use Isotrex?

If you forget to use Isotrex, skip the missed application and continue to use it as scheduled at your usual time. Do not use double the amount. 

Side Effects

Common side effects include: 

  • Red, peeling skin- this is common in the first week of using the treatment 

  • A stinging or slightly painful sensation across the skin 

  • Irritated skin 

  • Tenderness 

  • Burning sensation 

  • Dry skin 

  • Itchy skin 


You may also experience: 

  • Altered skin pigmentation 

  • Photosensitivity 


Isotrex should not be used if: 

  • You are pregnant or trying to get pregnant 

  • You are allergic to Isotretinoin or any of the other ingredients 

  • You are breastfeeding 


Consult your doctor before using Isotrex if any of the following apply to you: 

  • If you have ever had skin cancer 

  • If you have a family history of skin cancer 

  • If you have experienced skin irritation after using similar medicines in the past 

  • If you have a skin condition including eczema, rosacea or perioral dermatitis 

  • If direct sunlight causes skin reactions

Drug Interactions

Using additional acne treatments alongside Isotrex is not recommended. This can cause or exacerbate skin irritation and it may result in Isotrex being less effective. 

Will Isotrex affect my fertility?

Isotrex will not have an affect on your fertility. However, the medicine can harm an unborn baby so it's not suitable to use if you are trying to get pregnant. Leave at least 1 month after finishing Isotrex treatment before actively trying for a baby. 

Is Isotrex suitable to use during pregnancy?

Isotrex is not safe to use during pregnancy. It can harm an unborn baby so it's important not to use it if there is a chance you may be pregnant. 

Can I drink alcohol while using Isotrex?

You can drink alcohol while using Isotrex. 

Can I donate blood while using Isotrex?

You will not be able to donate blood while you are using Isotrex. You will need to wait at least one month after completing your treatment to be able to give blood. This is because it can be harmful to a baby if the blood is given to a pregnant woman. 

Treatment Options

Alternatives to Isotrex

Over-the-counter remedies are available to treat mild acne. These contain Benzoyl peroxide and come in the form of creams or gels. If these prove to be ineffective, prescription medication for acne includes: 


  • Topical retinoids (such as Isotrex Gel) 

  • Topical antibiotics 

  • Combination creams such as Epiduo Gel (containing both Benzoyl peroxide and retinoids) 

  • Oral antibiotics 

  • The combined contraceptive pill (for healthy women with no heart or blood pressure issues) 

  • Oral Isotretinoin

How to prevent acne?

It's not always possible to prevent acne but you may be able to reduce further breakouts by: 


  • Washing your face twice a day with oil-free cleanser 

  • Moisturising to prevent your skin from drying out 

  • Using non-comedogenic cosmetics 

  • showering after exercise 

  • Using topical acne treatments to prevent spots 

Home remedies for acne

There are home remedies you can try to treat mild acne or occasional breakouts of spots. These tend to be natural Antiseptics and Anti-inflammatories such as: 

  • Tea tree oil 

  • Witch Hazel 

  • Honey 

  • Aloe Vera 

  • Jojoba oil 

  • Sea salt

How to cope with acne

Acne can have a negative impact on your self esteem given the way it alters your appearance. It can be frustrating to deal with but it's important to remember that acne won't last forever and that it will disappear with the right treatment. Talking to others about how you feel can help and there are online resources and forums which accommodate this. If you continually feel low to the point where it affects your day to day life, speak to your doctor about how you are feeling. 

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