Metronidazole (Zidoval) Gel

Buy Zidoval metronidazole gel to treat BV effectively

  • Contains the antibiotic metronidazole, an effective treatment for bacterial vaginosis (BV)
  • Comes as a 7-day course, and is applied directly inside the vagina
  • Available from £26.99 + prescription fees and delivery costs

Our prices

Strength Quantity Price Stock
0.75%1 x 40g tube£26.99Out of Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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Dr Samantha Miller

Reviewed by Dr Samantha Miller MB ChB
(2017, University of Glasgow)
GMC number: 7561464

Information last reviewed 20/04/2021


What is Zidoval gel?

Zidoval gel is an antibiotic gel used to treat an infection of the vagina called bacterial vaginosis (or BV for short). The gel is applied directly into the vagina where it starts to work right away.

How does Zidoval gel work?

Zidoval gel is applied directly to the site of the infection, inside the vagina. It works by killing the bacteria that are causing the infection.

How long does Zidoval gel take to work?

Zidoval gel will start to work right away, and you can expect your symptoms to improve within a few days of beginning treatment. Bacterial vaginosis will usually clear up completely within 5–7 days. 

Metronidazole gel summary


Once applicator full, applied inside the vagina, once each night before bed

Type of Medicine

Nitroimidazole antimicrobial


Raidly taken up by bacterial cells, where it is metabolised into poisonous materials that affect bacterial processes, killing the bacteria

Available Size

40g tube

Available Strengths


Active Ingredient



From £26.99 per tube

Side Effects

Can include lack of appetite, nausea, vomiting, headache, dizziness, thrush, vaginal discharge, abdominal cramps, pelvic pain


Active ingredients

The active ingredient in Zidoval gel is 0.75% metronidazole.

Inactive ingredients

The inactive ingredients are carbopol 974P, disodium edetate, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), propylene glycol (E1520), sodium hydroxide (E524) and purified water.

Which ingredients can cause an allergic reaction?

Methyl parahydroxybenzoate and propyl parahydroxybenzoate are 2 ingredients present in this gel which may cause allergic reactions. This may possibly be a delayed reaction. It also contains propylene glycol which may cause local skin irritation where applied. Get immediate medical help if you notice signs of an allergic reaction such as hives, difficulty breathing, swelling of the face/lips, and dizziness.


How to use Zidoval gel

Zidoval gel is inserted inside the vagina once a day at night time using one of the disposable applicators provided. Before starting, wash and dry your hands. Some brands will have prefilled applicators ready for use, while others come as a tube of gel that you measure into the applicator. Read over the instructions given with the gel and use as directed. When you're ready, get into a comfortable position and insert the applicator into the vagina. Press down on the plunger until it stops then carefully slide the applicator back out. Always use the medicine for the time period prescribed, even if your symptoms are better, to make sure the infection is treated properly. 

When can I stop using Zidoval gel?

Always use Zidoval gel for the length of time your doctor has prescribed otherwise the infection may return, even if your symptoms clear up before this. For treating bacterial vaginosis the treatment time is usually five days.

Can I use Zidoval during the day?

Zidoval gel used for treating BV should ideally be inserted at night time before you go to bed for maximal effectiveness.

Side Effects

Zidoval side effects

Like all medications, Zidoval metronidazole gel can cause side effects. If you get any side effects, it’s important to talk to your doctor or pharmacist, this includes side effects not listed here. 

Common side effects (may affect up to 1/10 people) include: 

  • Thrush
  • Vaginal discharge
  • Itching, burning or discomfort of the skin
  • Pelvic pain or discomfort
  • Abdominal pain or cramps
  • Lack of appetite
  • Unusual feeling of the tongue 
  • Vomiting 
  • Headache
  • Dizziness 

Less common side effects (may affect up to 1/100 people) include: 

  • Nausea
  • Depression
  • Tiredness
  • Irritability
  • Tingling in the fingers or toes
  • Changes to bowel habit e.g. bloating, constipation or diarrhoea
  • A dry mouth or feeling thirsty
  • Altered taste, including a metallic taste
  • Muscle cramps
  • Bleeding or spotting between periods
  • Swelling around the vulva 
  • Symptoms of a urinary tract infection e.g. needing to pass urine more often, pain on passing urine
  • Difficulty sleeping

How to cope with Zidoval side effects

If you experience nausea then stick to small, simple meals and avoid foods that are rich or spicy. Drink plenty of water in small amounts especially if you vomit or get diarrhoea. If it lasts for more than 24 hours then consult your doctor. Eating plain foods and drinking water can help to ease a metallic taste in your mouth.

Drug interactions

You should avoid using other types of medicines that are used inside of the vagina while you are using Zidoval gel. The treatment is unlikely to interact with any other medicines but there is a possibility it may affect: 

  • Ciclosporin, a medication used to treat some autoimmune conditions
  • Fluorouracil, a medication used for skin problems and cancer
  • Lithium, a medication used for mental health conditions
  • Medications used to prevent blood clots e.g. warfarin 

Speak to your prescriber if you are taking any regular medications.

Zidoval and pregnancy

Consult your doctor before using Zidoval if you are pregnant as it may not be suitable.

Zidoval and alcohol

You should not drink alcohol while using Zidoval as it can cause adverse side effects such as nausea, vomiting, headache and confusion. After finishing your treatment you should wait 2 days before drinking alcohol. 


Do not use Zidoval gel if you are allergic to: 

  • Metronidazole or any of the ingredients 
  • Any other type of nitroimidazole antibiotic
  • Parabens 

Consult your doctor if you: 

  • Have ever experienced blood problems or a blood disease 
  • Think you have thrush
  • Are on your period 
  • Are scheduled to have a blood test, as this medication can cause abnormal results

Can Zidoval cause bleeding?

Zidoval gel is associated with a change in vaginal bleeding in up to 1 in 100 women, however, this should settle once treatment has been completed. If you experience unexplained vaginal bleeding after treatment, this may be a sign of a sexually transmitted infection. You can get tested at a local sexual health clinic or by using one of our discreet at home testing kits. If you continue to have unusual vaginal bleeding, you should speak to your doctor. 

Does Zidoval sting/burn when you use it?

Burning or irritation of the vagina is a possible side effect when using Zidoval gel. However, the majority of women don't experience side effects with Zidoval gel.

Can I use a tampon whilst using Zidoval?

It's not recommended to use Zidoval while you are on your period and you shouldn't wear a tampon during Zidoval treatment as it can soak up the gel, stopping it from being absorbed by the vagina. You can wear a sanitary pad for comfort as you may experience a slight leakage while you are using the gel. If you have troublesome symptoms of BV during your period, it may be best to wait until you are no longer bleeding to commence treatment. Speak to your doctor if this is the case.

Treatment Options

What are the different uses of Zidoval?

Zidoval gel is primarily used to treat bacterial vaginosis, however, metronidazole gel is also used to treat skin infections and a skin condition called rosacea. 

Zidoval tablets vs metronidazole gel

Zidoval gel contains metronidazole which is also available in the form of oral tablets. Both options are effective at treating bacterial vaginosis so which option you choose mainly depends on your personal preference. The tablets tend to produce more side effects such as nausea and interfere with other medications such as warfarin. Oral tablets also tend to produce a more severe reaction when mixed with alcohol. Zidoval gel does not cause as many side effects, however, some people are uncomfortable with the idea of vaginal application.


Can I still have sex while using Zidoval?

You should avoid sex while you have symptoms of any vaginal infection, and while you are using Zidoval gel. Sexual intercourse can hinder the ability of Zidoval to remove the bacteria causing infection. In addition, ingredients in Zidoval gel may cause condoms to break, potentially placing you at risk of pregnancy. It’s best to wait until you have completed your treatment, and your symptoms have resolved before having sex. 

Is Zidoval an antibiotic?

Zidoval is an antibiotic that kills the bacteria causing the infection.

Is Zidoval gel suitable for sensitive skin?

Zidoval is suitable for sensitive skin and in fact a similar product is often used to treat skin conditions like rosacea. If you have an allergy to Zidoval, you should not use it. If you develop signs of skin irritation while using Zidoval, speak to your doctor for alternatives.

Does Zidoval cause thrush?

Thrush is a side effect of Zidoval gel. Common symptoms of thrush include itching, redness and a white cottage cheese-like discharge from the vagina. Ask your pharmacist for advice on an appropriate treatment, Zidoval gel will not treat thrush.

Is Zidoval supposed to leak out?

It is normal for some of the Zidoval gel to leak out of the vagina during treatment. It's recommended to wear a light sanitary pad while you are using Zidoval. 

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I moved 150 miles from my GP (to uni) and was unable to go home or visit a walk in for another 2 days due to being at work (12.5 hour shifts). I filled out a quick form - and 1.5 days later I had my antibiotics delivered to my door and I am on the mend. 10/10.