Buy Nexium for a tried and trusted acid reflux treatment

Nexium, also known as Esomeprazole, is a proton pump inhibitor that treats acid reflux, heartburn, stomach ulcers and Gastroesophageal Reflux Disease (GORD).

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Strength Quantity Price Stock
20 mg28 tablets£35.99In Stock
20mg56 tablets£66.99In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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Virginia Chachati

Reviewed by Virginia Chachati MPharm
(2013, University College London)
GPhC Registration number: 2087654

Information last reviewed 03/03/21


What is Nexium?

Nexium is a type of medicine called a proton pump inhibitor which treats acid reflux, heartburn, stomach ulcers and Gastroesophageal Reflux Disease (GORD). The generic name of Nexium is Esomeprazole.

How does Nexium work?

Nexium works by blocking proton pumps that line the wall of the stomach. This prevents excess stomach acid production to prevent and reduce acid reflux.

How long does Nexium take to work?

Nexium will start to work within one or two hours of taking it. It may take two to three days to feel a lot better. However, it can take a number of weeks to complete a treatment course, depending on your health problem.

Is Nexium safe for long term use?

Long term use of Nexium for three months or more can cause side effects such as:

  • Feeling tired
  • Feeling dizzy
  • Confusion
  • Shaking
  • Irregular heartbeat
  • Muscle twitching

After one year of using Nexium there is an increased risk of experiencing:

  • Fractured bones
  • Gut infections
  • Vitamin B12 deficiency

Long term use of Nexium should be monitored by a doctor.

Are acid reflux and heartburn the same thing?

Heartburn is a momentary sensation, whereas acid reflux can become a long-term problem. Acid reflux causes a number of symptoms, the main one being heartburn. Acid reflux occurs when the stomach produces excess acid, causing it to travel back up the oesophagus (food pipe). The resulting heartburn feels like an uncomfortable, burning pain in the middle of your chest. If this happens more than twice a week it's known as Gastroesophageal Reflux Disease (GORD). 


Active ingredients

The active ingredient in Nexium is Esomeprazole.

Inactive ingredients

The inactive ingredients in Nexium are glycerol monostearate 40-55, hyprolose, hypromellose, iron oxide (20 mg reddish-brown, yellow, 40 mg reddish brown) (E172), magnesium stearate, methacrylic acid ethyl acrylate copolymer (1:1) dispersion 30 per cent, microcrystalline cellulose, synthetic paraffin, macrogol, polysorbate 80, crospovidone, sodium stearyl fumarate, sugar spheres (sucrose and maize starch), talc, titanium dioxide (E171), triethyl citrate.

Which ingredients can cause an allergic reaction?

Nexium is an anti-acid that has a good safety profile, however, it can cause a severe allergic reaction in some people. This reaction will present as facial swelling, a rash, itching, trouble breathing, chest tightness and, severe dizziness. Please seek emergency medical attention if you experience any of these symptoms after taking the medication.


How to take Nexium?

Nexium is usually taken once a day without food. You should swallow the tablet whole with a glass of water, or dissolve it carefully in water if you have trouble swallowing tablets. The amount of Nexium you have to take will depend on why you are taking it. Always follow the instructions given to you by your doctor or pharmacist.

How long can I take Nexium for?

How long you take Nexium will depend on why it has been prescribed for you. Always follow the instructions your doctor gives you on how to take Nexium. A treatment course is typically two to eight weeks long and after this, you can use Nexium when you need to.

What should I do if I forget to take Nexium?

If you forget to take Nexium, take it as soon as you remember. There is no need to take a missed dose at the same time as your next dose, try to make sure they are a few hours apart. If you are unsure what to do after you miss a dose of Nexium, speak to your doctor or pharmacist for advice.

What should I do if I take too much Nexium?

If you take too much Nexium, it is unlikely to cause problems. However, if you experience any of the following side effects, see your doctor:

  • Increased sweating
  • Sleepiness
  • Faster heartbeat
  • Confusion
  • Agitation
  • Blurred vision

What food and drink should I avoid while taking Nexium?

You should only take Nexium with water. Try to avoid food and drinks which commonly trigger acid reflux or heartburn. These are:

  • Spicy foods
  • Oily foods
  • Fatty foods
  • Tomatoes
  • Chocolate
  • Coffee
  • Alcohol
  • Onions
  • Citrus fruits
  • Fizzy drinks


Always take Nexium as your doctor has prescribed. This will depend on your condition and symptoms. Here are some typical treatment courses:

  • For heartburn caused by GORD, with damage to the food pipe, the recommended dose is 40 mg once a day for a minimum of four weeks. This will eventually be reduced to 20 mg a day.
  • If there is no damage to the food pipe the daily dose is 20 mg until your condition has improved.
  • For stomach ulcers caused by the Helicobacter pylori bacteria the recommended dose is 20 mg twice a day alongside antibiotics.
  • For stomach ulcers caused by anti-inflammatory drugs the recommended dose is 20 mg once daily for four to eight weeks.

Side Effects

Side Effects

Common side effects after taking Nexium may include:

  • Diarrhoea
  • Flatulence
  • Stomach pain
  • Constipation
  • Nausea
  • Headaches
  • Vomiting

Uncommon side effects of Nexium can include:

  • Swelling in the ankles and feet
  • Dry mouth
  • Feeling dizzy
  • Difficulty sleeping
  • Vertigo
  • Pins and needles sensation
  • Skin rash
  • Hives
  • Itchiness
  • Fractures of the hip, wrist or spine after the high dose, long term use

Rare side effects of Nexium can include:

  • A reduction in white blood cells
  • A lowered level of sodium in the blood
  • Feeling agitated or confused
  • Feeling depressed
  • Changes to taste buds
  • Blurred vision
  • Breathlessness and wheezing
  • Inflammation inside the mouth
  • Thrush
  • Hair loss
  • Photosensitivity
  • Pain in the muscles or joints
  • Lack of energy and feeling unwell

Signs of an allergic reaction to Nexium include:

  • Swelling of the lips, tongue or throat
  • Wheezing and having difficulty breathing  
  • Skin rash
  • Fainting
  • Jaundice

If you experience any of these symptoms seek emergency medical attention straight away.

Taking Nexium may mask signs of other diseases. Tell your doctor if you have any of these symptoms while taking Nexium:

  • Sudden weight loss which is unexpected
  • Having difficulty swallowing
  • Stomach pain and indigestion
  • Vomiting food or blood
  • Passing black stools


Do not take Nexium if:

  • You have experienced an allergic reaction to any other types of proton pump inhibitors
  • You are taking medicines that contain Nelfinavir to treat HIV

Extra care should be taken if:

  • You have severe liver or kidney problems
  • You have experienced a skin reaction in the past after taking medication to control stomach acid
  • You are due to have a blood test

Treatment Options

Alternatives to Nexium

Alternative proton pump inhibitors include Lansoprazole, Pantoprazole, Omeprazole and Rabeprazole. In addition, antacids can relieve the symptoms of heartburn, but they are not suitable for long-term use. Examples of antacids include Gaviscon and Rennies.

Can I take Nexium with antacids?

Antacids are suitable to take alongside Nexium. You should leave at least two hours before or after taking each type of medicine.

Can I take Nexium with painkillers?

Some painkillers are safe to take alongside Nexium. If you take painkillers regularly or are experiencing pain, check with your doctor or pharmacist on the best way to take them alongside Nexium.

Can lifestyle changes help?

Lifestyle changes can help you reduce and prevent acid reflux. These include:

  • Maintaining a healthy weight
  • Quitting smoking
  • Managing stress
  • Eat smaller, more frequent meals
  • Avoiding spicy, oily and fatty foods
  • Cutting down on caffeine and alcohol
  • Eating your last meal of the day at least two to three hours before going to bed

What causes acid reflux?

Factors that can cause acid reflux include:

  • Spicy, oily and fatty foods
  • Coffee
  • Chocolate
  • Alcohol
  • Smoking
  • Stress
  • Pregnancy
  • Certain medicines
  • Being overweight
  • A Hiatus hernia

How can I treat acid reflux naturally?

There are lifestyle changes you can make to prevent acid reflux or heartburn. These include:

  • Stopping smoking
  • Avoiding foods that are known triggers
  • Elevating your head and chest with extra pillows while you are sleeping
  • Cut down on caffeine and alcohol
  • Don't lie down straight after eating
  • Eat smaller portions of food to avoid overeating


Can I drink alcohol while taking Nexium?

Drinking alcohol while taking Nexium is not recommended. Alcohol can irritate the stomach lining and make your symptoms worse.

Nexium and pregnancy

Speak to your doctor before taking Nexium if you are pregnant or planning a baby. You should not use Nexium while breastfeeding as it is not known whether or not Nexium is passed into breast milk.

Will Nexium affect my contraception?

Nexium is not known to affect hormonal or non-hormonal methods of contraception. However, Nexium can reduce the effectiveness of the ellaOne emergency contraceptive tablet. If you are taking Nexium and need to take the morning after pill, speak to your doctor or pharmacist for advice.

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