Buy Omeprazole Online from a UK pharmacy - 10mg & 20mg

Complete a short consultation reviewed by our UK registered team to buy Omeprazole online in the UK. Omeprazole helps alleviate the uncomfortable symptoms of acid reflux.

Our prices

Medicine Strength Quantity Price Stock
Omeprazole capsules10mg28 capsules£8.99In Stock
Omeprazole capsules10mg56 capsules£13.99In Stock
Omeprazole capsules20mg28 capsules£15.99In Stock
Omeprazole capsules20mg56 capsules£28.99In Stock
Omeprazole dispersible20mg28 tablets£19.99In Stock
Omeprazole dispersible20mg56 tablets£38.99In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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Virginia Chachati

Reviewed by Virginia Chachati MPharm
(2013, University College London)
GPhC Registration number: 2087654

Information last reviewed 23/03/2022


What is Omeprazole?

Omeprazole is a treatment for acid reflux, gastroesophageal reflux disease (GERD / GORD), heartburn and stomach ulcers. Omeprazole is a type of medicine called a proton pump inhibitor (PPI). It comes in a variety of forms including capsules, dispersible tablets and a smaller pack of Omeprazole available over the counter.

How does Omeprazole work?

Omeprazole works by decreasing the amount of acid in your stomach. It does this by blocking an acid-secreting cell in the stomach known as a proton pump. Blocking this cell directly reduces the amount of stomach acid being pumped into the stomach from where it is produced.

What is Omeprazole used for?

Omeprazole is used to control conditions where a problematic excess of acid is in the stomach or conditions that benefit from having less stomach acidity. Some common conditions are:

  • GORD (gastroesophageal reflux disease) 
  • Acid reflux (Heartburn)
  • Stomach ulcers
  • Erosive esophagitis

Each of these conditions may have different dose requirements, so always talk to your doctor about what dose is right for your condition.

Omeprazole Summary


Take ONE capsule in the morning or as directed by your GP.

Type of medicine

Proton Pump Inhibitor (PPI)


Reduces stomach acid, relieving acid reflux symptoms

Available Size

28 to 56

Available Strengths

10mg & 20mg

Active Ingredient



From £8.99

Side Effects

May include headaches, stomach discomfort, nausea and flatulence.


Active ingredients

The active ingredient in omeprazole capsules is omeprazole.

Inactive ingredients

The inactive ingredients in omeprazole capsules are sugar spheres (corn starch and sucrose), sodium lauryl sulfate, disodium phosphate, mannitol, hypromellose, polyethylene glycol 6000, talc, polysorbate 80, titanium dioxide, eudragit L30-D55 (poly(methacrylic acid, ethyl acrylate)), gelatin, quinine yellow (E104) and titanium dioxide (E171).

Please Note: Different brands of generic omeprazole could contain different inactive ingredients than those listed here. Check the patient information leaflet provided for full details


How to take Omeprazole

Always take omeprazole as instructed by a doctor or pharmacist. It is usually taken once daily in the morning, although your doctor may recommend you take an additional evening dose for certain conditions. 

Swallow one omeprazole capsule with water about an hour before eating. Dispersible tablets should be dissolved in a small glass of water before you swallow the mixture. If you forget to take a dose, don’t worry, just take the next one as planned. There is no need to take a double dose to make up for a missed one.

Capsules vs Dispersible Tablets

Omeprazole can be purchased in the form of capsules that dissolve in the stomach, and tablets that can be dissolved in water for those who struggle with swallowing capsules. A branded version of omeprazole, Losec, is also available in the form of tablets that are placed in the mouth and dissolved on the tongue.

Side Effects

Omeprazole side effects

Like any medicine, Omeprazole can cause side effects in some patients but not everyone will get them. Many side effects are directly related to the conditions themselves such as stomach upset.

Common side effects of omeprazole may affect up to 1 in 10 people can include:

  • Headache
  • Diarrhoea, stomach pain, constipation or wind
  • Nausea or vomiting
  • Benign polyps in the stomach

There are other potential side effects that affect less than 1% of people who take the medicine. For these side effects, it is recommended to read the patient information leaflet. If you experience any rare but severe side effects, seek medical attention.

How to improve omeprazole side effects

Omeprazole should be taken approximately an hour before eating. If this causes any sickness or nausea, try drinking small sips of water to stay hydrated and eat smaller portions at mealtimes. Drinking water will also help prevent constipation. Eating foods that are rich in fibre and exercising regularly can also help. Stomach pain or discomfort can be soothed by holding a hot water bottle against your abdomen and avoiding foods such as onions, peas, beans and lentils which can cause wind.

Warnings and Precautions

This medicine may not be suitable for everyone. Our doctors will make their assessment on whether the medicine is right for you based on your health assessment.

Do not take omeprazole if:

  • You have experienced an allergic reaction to any of the ingredients in this medicine
  • You are allergic to other medicines containing proton pump inhibitors

Certain symptoms may indicate a more serious condition that requires more urgent or different medical care. Before taking omeprazole, speak to your doctor or pharmacist if:

  • You lose a lot of weight for no reason and have problems swallowing
  • You get stomach pain or indigestion
  • You begin to vomit food or blood
  • You pass black stools
  • You experience severe or persistent diarrhoea
  • You have severe liver problems
  • You have ever had a skin reaction after treatment with a medicine similar to omeprazole
  • You get a rash on your skin, especially in areas exposed to the sun

Drug interactions

Before taking omeprazole, tell your doctor or pharmacist if you are taking any other medicines, including those purchased over the counter without a prescription. This is particularly important as PPIs like omeprazole cause result in absorption changes to your other medicines, causing them to not work as intended increasing the risk of an adverse health event.

Omeprazole and alcohol

While there is no direct danger from drinking alcohol while taking omeprazole, drinking alcohol is a common cause of acid reflux. For best results, avoid alcohol if you have acid reflux.

Treatment Options

Alternative Treatments

There are many different reflux medicines available. Most belong to the same family of medicines PPIs such as esomeprazole and pantoprazole. Alternatively, there are other over the counter treatments such as antiacids which can neutralise stomach acid to reduce acidity.

Losec vs omeprazole

Losec is a brand name for the generic medicine called omeprazole. Both contain omeprazole as the active ingredient and work in exactly the same way, although the generic version is cheaper.

Prescription omeprazole vs omeprazole over the counter

Omeprazole can be bought over the counter for self-treatment of acid reflux that occurs regularly (more than twice per week). It is the same as the 20 mg dose of prescription omeprazole, but should not be taken for longer than 2 weeks without speaking to a doctor. Prescription omeprazole is available in 10 mg, 20 mg, 40 mg and in larger, better value pack sizes.


How long does Omeprazole take to work?

Omeprazole starts to work within 1 hour but the full effect may take days to weeks depending on the severity of your condition. Depending on your symptoms, you may need to take omeprazole for 2 to 4 weeks. 

How long should I take Omeprazole?

If you are self-treating with over the counter omeprazole, you should not take it for more than 14 days without seeing a doctor. If you are prescribed the treatment by a doctor, ensure you follow their directions for the treatment duration as it can vary depending on the condition.

Can Omeprazole be crushed or divided?

Omeprazole comes in the form of hard-coated capsules, which should be swallowed whole with water and should not be split. There are omeprazole tablets you can dissolve in water or orodispersible tablets which dissolve in the mouth.

Why do you need to take Omeprazole in the morning?

Omeprazole should be taken in the morning or at least 1 hour before a meal. This will allow it to be absorbed into the stomach lining before acid production begins with food. If you are taking omeprazole twice daily, you should take one dose in the morning and one in the evening.

How soon can you drink coffee after taking omeprazole?

You should wait at least one hour after taking omeprazole before you drink a coffee. This gives the medicine enough time to absorb and provide reflux protection for most people.

Can I take pain medicine with Omeprazole?

Yes however you should avoid taking anti-inflammatory painkillers if possible such as ibuprofen or aspirin if you have heartburn or ulcers, as they can make these conditions worse.

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