Order omeprazole to help ease acid reflux

Omeprazole works by blocking the production of stomach acid. It helps alleviate symptoms of acid reflux. This also allows any damage in the oesophagus to heal.

Our prices

Medicine Strength Quantity Price Stock
Omeprazole capsules10mg28 capsules£8.99In Stock
Omeprazole capsules10mg56 capsules£13.99In Stock
Omeprazole capsules20mg28 capsules£15.99In Stock
Omeprazole capsules20mg56 capsules£28.99In Stock
Omeprazole dispersible20mg28 tablets£19.99In Stock
Omeprazole dispersible20mg56 tablets£38.99In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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Virginia Chachati

Reviewed by Virginia Chachati MPharm
(2013, University College London)
GPhC Registration number: 2087654

Information last reviewed 03/07/2021


What is omeprazole?

Omeprazole is a treatment for acid reflux and gastroesophageal reflux disease (GORD), heartburn and stomach ulcers. It is available as capsules, dispersible tablets and over the counter medicine.

How does omeprazole work?

Omeprazole is a type of medicine called a proton pump inhibitor (PPI). It works by blocking proton pump production of stomach acid in the stomach, settling the symptoms of acid reflux and allowing the oesophagus to heal.

Omeprazole for GORD

GORD (gastroesophageal reflux disease) is characterised by frequent acid reflux and can cause some minor damage to the esophagus. For treatment of GORD, Omeprazole is usually taken once daily for 4 to 8 weeks at the dosage recommended by your doctor.

Omeprazole for acid reflux

If you are experiencing acid reflux regularly, you can start taking omeprazole daily until you can see a doctor. If you are self-treating with over the counter omeprazole, you should not take it for longer than 2 weeks without checking in with a doctor. If you experience acid reflux occasionally, some simple lifestyle changes such as eating smaller meals and avoiding trigger foods can help.

How long does omeprazole take to work?

Omeprazole starts to work within 1 hour, but you may not start to feel better for 2 to 3 days. Depending on your symptoms, you may need to take omeprazole for 2 to 4 weeks. If you are self-treating with over the counter omeprazole, you should not take it for more than 2 weeks without seeing a doctor. For treatment of GORD, you may need to continue treatment for 8 weeks.


Active ingredients

The active ingredient in omeprazole capsules is omeprazole.

Inactive ingredients

The inactive ingredients in omeprazole capsules are sugar spheres (corn starch and sucrose), sodium lauryl sulfate, disodium phosphate, mannitol, hypromellose, polyethylene glycol 6000, talc, polysorbate 80, titanium dioxide, eudragit L30-D55 (poly(methacrylic acid, ethyl acrylate)), gelatin, quinine yellow (E104) and titanium dioxide (E171).

Please Note: Different brands of generic omeprazole could contain different inactive ingredients than those listed here. Check the patient information leaflet provided for full details

Which ingredients can cause an allergic reaction?

Omeprazole is an acid reflux medication that is rarely associated with a severe allergic reaction, however, has been linked to some cases when used alongside antibiotics. If you are allergic to any of the ingredients of this medication (active or inactive), please do not take this medication and let your prescribing doctor know. Get medical help as soon as possible is you notice these symptoms of a severe allergic reaction: lip/eye swelling, hives, finding it hard to breathe and dizziness.


How to take omeprazole?

Always take omeprazole as instructed by a doctor or pharmacist. It is usually taken once daily in the morning, although your doctor may recommend you take an additional evening dose. Swallow one omeprazole capsule with water about an hour before eating, without splitting or chewing the capsule. Dispersible tablets should be dissolved in a small glass of water before you swallow the mixture. If you forget to take a dose, don’t worry, just take the next one as planned. There is no need to take a double dose to make up for a missed one.

Omeprazole dosage

For treatment of persistent acid reflux or GORD, the recommended dose is 10 mg taken once daily for 4 to 8 weeks, or 20 mg if the oesophagus is damaged. If the oesophagus has not healed within 8 weeks, your doctor may recommend a dose of 40 mg once daily for a further 8 weeks.

For the treatment of stomach ulcers, the recommended dose is 20 mg taken once daily for 4 weeks. If ulcers have not healed, your doctor may increase the dose to 40 mg per day for a further 4 to 8 weeks.

Can omeprazole be crushed or divided?

Omeprazole comes in the form of hard-coated capsules, which should be swallowed whole with water and should not be split. There are omeprazole tablets you can dissolve in water or orodispersible tablets which dissolve in the mouth.

Why do you need to take omeprazole in the morning?

Omeprazole should be taken in the morning or at least 1 hour before a meal. This will allow it to be absorbed into the stomach lining before acid production begins with food. If you are taking omeprazole twice daily, you should take one dose in the morning and one in the evening.

Side Effects

Omeprazole side effects

Omeprazole can cause side effects in some patients. 

Common side effects of omeprazole may affect up to 1 in 10 people. These include:

  • Headache
  • Diarrhoea, stomach pain, constipation or wind
  • Nausea or vomiting
  • Benign polyps in the stomach

Uncommon side effects of omeprazole, affecting up to 1 in 100 people, can include:

  • Swelling of the feet or ankles
  • Insomnia
  • Dizziness, tingling sensation, feeling sleepy
  • Vertigo
  • Changes in blood tests monitoring liver function
  • Skin rash, hives or itchy rash
  • Generally feeling unwell and lacking energy
  • Increased risk of fracture of the hip, wrist or spine

Rare side effects (1 in 1,000 people) of omeprazole can include:

  • Blood problems such as reduced number of white blood cells or platelets
  • Low levels of sodium in the blood
  • Agitation, confusion or depression
  • Taste changes
  • Blurred vision
  • Bronchospasm
  • Dry mouth
  • Inflammation of the inside of the mouth
  • Alopecia
  • Rash on exposure to sunshine
  • Joint or muscle pains
  • Severe kidney problems
  • Increased sweating
  • Liver problems, including jaundice, which can cause yellow skin, dark urine and tiredness
  • Thrush

Very rarely, (1 in 10,000 cases) the following side effects of omeprazole might be experienced:

  • Aggression
  • Hallucinations
  • Severe liver problems leading to liver failure and inflammation of the brain
  • Muscle weakness
  • Enlarged breasts in men
  • If you experience any of the following rare side effects, stop taking omeprazole and contact a doctor immediately:
  • Severe allergic reaction, characterised by sudden wheezing, swelling of the lips, tongue or throat, body rash, fainting, and difficulty swallowing.
  • Reddening of the skin with blisters, peeling, or severe blistering of the skin around the eyes, nose, lips, or genitals.
  • Symptoms of liver failure, including jaundice (yellowing of the skin and whites of the eyes), dark-coloured urine and tiredness.
  • Shortness of breath, tiredness, dizziness, bleeding or bruising, which may be caused by a reduction in red or white blood cells or platelets in the blood.
  • Infection with symptoms such as fever and severely reduced general condition, or fever with symptoms of a local infection such as pain in the neck, throat or mouth or difficulty urinating. In very rare cases omeprazole may affect white blood cells.


Do not take omeprazole if:

  • You are allergic to any of the ingredients in this medicine
  • You are allergic to other medicines containing proton pump inhibitors

Before taking omeprazole, speak to your doctor or pharmacist if:

  • You lose a lot of weight for no reason and have problems swallowing
  • You get stomach pain or indigestion
  • You begin to vomit food or blood
  • You pass black stools
  • You experience severe or persistent diarrhoea
  • You have severe liver problems
  • You have ever had a skin reaction after treatment with a medicine similar to omeprazole
  • You get a rash on your skin, especially in areas exposed to sun

Drug interactions

Before taking omeprazole, tell your doctor or pharmacist if you are taking any other medicines, including those purchased over the counter without a prescription. In particular, tell your doctor or pharmacist if you are taking any of the following:

  • Ketoconazole, itraconazole, posaconazole or voriconazole
  • Digoxin for heart problems
  • Diazepam
  • Phenytoin for epilepsy
  • Blood thinners such as warfarin or other vitamin K blockers
  • Rifampicin for tuberculosis
  • Atazanavir for HIV infection
  • Tacrolimus
  • Methotrexate
  • St John’s Wort
  • Cilostazol
  • Saquinavir for HIV infection
  • Clopidogrel
  • Erltinib
  • Clarithromycin
  • Nelfinavir for HIV infection

How to cope with omeprazole side effects?

Omeprazole should be taken approximately an hour before eating. If this causes any sickness or nausea, try drinking small sips of water to stay hydrated and eat smaller portions at mealtimes. Drinking water will also help prevent constipation. Eating foods that are rich in fibre and exercising regularly can also help. Stomach pain or discomfort can be soothed by holding a hot water bottle against your tummy, and avoiding foods such as onions, peas, beans and lentils which can cause wind.

Omeprazole and alcohol

Drinking alcohol is a common cause of acid reflux. For best results, do not drink alcohol while taking omeprazole.

Omeprazole and pregnancy

Before taking omeprazole, tell your doctor if you are pregnant, think you might be pregnant or are planning a pregnancy.

Treatment Options

Omeprazole vs omeprazole dispersible

Omeprazole can be purchased in the form of capsules which dissolve in the stomach, and tablets which can be dissolved in water for those who struggle with swallowing capsules. A branded version of omeprazole, Losec, is also available in the form of tablets which are placed in the mouth and dissolved on the tongue.

Losec vs omeprazole

Losec is a brand name for the generic medicine called omeprazole. Both contain omeprazole as the active ingredient and work in exactly the same way, although the generic version is cheaper.

Prescription omeprazole vs omeprazole over the counter

Omeprazole can be bought over the counter for self-treatment of acid reflux that occurs regularly (more than twice per week). It is the same as the 20 mg dose of prescription omeprazole, but should not be taken for longer than 2 weeks without speaking to a doctor. Prescription omeprazole is available in doses higher than 20 mg.


Can I take paracetamol or ibuprofen with omeprazole?

It is fine to take paracetamol with omeprazole. But you should avoid taking anti-inflammatory painkillers such as ibuprofen or aspirin if you have heartburn or ulcers, as they can make these conditions worse.

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