Premique

Premique is a form of hormone replacement therapy (HRT) containing estrogens and progesterone. It is used to treat some of the effects of the menopause. If you would like to purchase HRT, simply complete a 2 minute online consultation and our UK registered doctors will review your answers, before issuing a prescription if appropriate. Our NHS registered pharmacy will dispense and dispatch your medicine in discreet packaging.

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0.625/5mg84 tablets26.99
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About

What is Premique?

Premique is a type of hormone therapy which is used to treat the symptoms of menopause. Menopause is where the ovaries stop producing eggs and typically occurs in women around the age of 50.

How does Premique work?

Premique works by balancing out the level of oestrogen in the body. As a naturally occurring hormone, the levels of oestrogen in the body begins to fall during the menopause. This causes symptoms like hot flushes, mood changes, night sweats, irregular periods and vaginal dryness or irritation. Conjugated oestrogen is one of the active ingredients in Premique, topping up the falling levels of oestrogen. It also contains medroxyprogesterone acetate which is a progesterone hormone. This works by balancing out the effect of oestrogen on the womb lining. 

Ingredients

Active ingredients

Conjugated estrogens and medroxyprogesterone acetate are the active ingredients contained in Premique. 

Inactive ingredients

The inactive ingredients are lactose monohydrate, sucrose (see section 2, Premique contains lactose monohydrate and sucrose), microcrystalline cellulose, hypromellose [(2208, K100M), (2910, E6), and (2910, E15)] , magnesium stearate, hydroxypropyl cellulose, polyethylene glycol 400, ethyl acrylate, methacrylate, titanium dioxide (E171), yellow iron oxide (E172), carnauba wax, and edible ink that contains black iron oxide (E172), propylene glycol and hypromellose.

Dosage

How to use Premique

Premique should be taken at around the same time each day. You can start taking it at any time. If you are switching from a different type of HRT that causes periods then you should wait until you finish your current pack. Premique is taken everyday of the month and does not produce a monthly bleed.

Premique dosage

The recommended dose of Premique is one tablet per day. Always take the amount prescribed by your doctor. 

Side Effects

Premique side effects

Side Effects associated with Premique include: 

  • Stomach problems 
  • Menstrual bleeding
  • Spotting
  • Thrush
  • Enlarged uterine fibroids 
  • Oedema 
  • Headaches
  • Migraines
  • PMS symptoms 
  • Depression
  • Anxiety 
  • Irritable mood
  • Tiredness
  • Dizziness 
  • Changes to sex drive
  • Leg cramps
  • High blood pressure
  • Discomfort in wearing contact lenses 
  • Rash
  • Itching
  • Chloasma 
  • Jaundice 
  • Pancreatitis 
  • Disease of the gallbladder 
  • Blood clots 

Contraindications

Premique should not be used if you:

  • Have a blood clot or have experienced one in the past
  • Have recently had a heart attack or stroke 
  • Have angina pectoris 
  • Have ever experienced breast cancer or endometrial cancer
  • Experience endometrial hyperplasia 
  • Have a condition which increases your risk of having a blood clot
  • Have liver disease 
  • Have porphyria 
  • Are pregnant or breastfeeding 
  • Are allergic to any of the ingredients 

Extra care should be taken if: 

  • You have a family history of breast cancer 
  • You have a history of benign breast lumps
  • You experience endometriosis 
  • You have fibroids in the womb 
  • You have a family history of blood clots 
  • You are obese 
  • You have severe varicose veins 
  • You have high blood pressure
  • You have heart failure
  • You have problems with your kidneys
  • You are diabetic 
  • You have high cholesterol
  • You have ever experienced Gallbladder disease 
  • You suffer from migraines 
  • You have systemic lupus erythematosus
  • You have epilepsy 
  • You have asthma 
  • You have a history of depression

Drug interactions

Certain medications can interfere with the way Premique works. Tell your doctor if you are taking:

  • Medication for HIV
  • Medication for epilepsy 
  • Medication for tuberculosis 
  • Metyrapone 
  • Aminoglutethimide
  • St John's wort 

Treatment Options

Premique vs other types of HRT

Premique is a type of low dose combined hormone replacement therapy. Women who have had a hysterectomy can take oestrogen only supplements. While Premique is an oral medication, HRT comes in different forms such as patches, gels or cream. The patch method provides greater convenience as you don't have to remember to take it each day and the gel is absorbed by the skin; both options do not increase your risk of a blood clot. The vaginal cream, pessary or ring helps to soothe dryness in the vagina. Which treatment is best for you will depend on which stage of the menopause you are at and what your medical history is like. Your doctor will be able to recommend the best one for you. 

Alternatives to HRT

Hormone replacement therapy may not be suitable for everyone but there are alternative options. A medicine called Tibolone works in a similar way to HRT. Rather than containing hormones it breaks down within the body to make them. Lifestyle changes can also help to ease the symptoms of menopause. Exercising regularly, stopping smoking, cutting down on caffeine and spicy food and staying cool during the night can ease hot flushes. A healthy, balanced diet will help prevent weight gain and maintain the health of the bones. Exercise can also help to manage stress and your mood, alongside giving yourself time to relax and take care of yourself.    

Lifestyle changes to improve menopause symptoms

Menopause symptoms can also be managed by making changes to your lifestyle to help your body to manage the discomfort. Keeping active and exercising will benefit your mood and stress levels while also reducing  hot flushes and helping to maintain a healthy weight. Hot flushes can also be reduced by cutting down on caffeine, spicy food and keeping cool during the night. Quitting smoking will also benefit you in this way, while reducing your likelihood of experiencing a heart attack, stroke or cancer. Taking up activities like yoga or meditation can help you to manage stress and be able to relax. 

Q&A

Can Premique cause depression?

Depression or changes to your mood is a potential side effect of Premique. This is because oestrogen can have an effect on your mood, particularly during times when your hormone levels are fluctuating. Signs of depression include feeling low, having negative thoughts, feeling lethargic and lacking in energy, losing interest in things and having trouble sleeping. If you experience this then see your doctor for advice on how to cope. 

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