Try Premique HRT to ease the menopause transition

Premique is a form of hormone replacement therapy (HRT) containing a type of oestrogen and progestogen. It’s used to treat some of the effects of the menopause..

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0.625/5mg84 tablets£26.99Out of Stock
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Dr Samantha Miller

Reviewed by Dr Samantha Miller MB ChB
(2017, University of Glasgow)
GMC number: 7561464

Information last reviewed 26/05/2021


What is Premique?

Premique is a type of hormone replacement therapy (HRT) which is used to treat the symptoms of menopause. Menopause is where the ovaries stop producing eggs and the level of oestrogen released drops. Menopause typically occurs in women around the age of 50.

How does Premique work?

Premique works by balancing out the level of oestrogen in the body. The level of oestrogen in the body begins to fall during the menopause. This causes symptoms like hot flushes, mood changes, night sweats, irregular periods and vaginal dryness. Conjugated oestrogen is one of the active ingredients in Premique, which effectively “tops up” the falling levels of oestrogen. It also contains medroxyprogesterone acetate which is a progestogen hormone. The progestogen hormone is essential to prevent undesirable effects of unopposed oestrogen on the womb lining.


Active ingredients

Primique contains 0.3mg of conjugated oestrogens and 1.5mg of medroxyprogesterone acetate.

Conjugated oestrogens are a mixture of oestrogens, obtained from the urine of pregnant horses, and made synthetically. Primique contains sodium sulfate conjugates of estrone, equilin, 17α-dihydroequilin, 17α-estradiol, 17β-dihydroequilin, 17α-dihydroequilenin, 17β-dihydroequilenin, equilenin, 17β-estradiol and Δ8,9-dehydro-estrone.

Inactive ingredients

The inactive ingredients are lactose monohydrate, microcrystalline cellulose, hypromellose 2208 (K100M), magnesium stearate, purified water, sucrose, hydroxypropyl cellulose, hypromellose 2910 (E6), hypromellose 2910 (E15), polyethylene glycol 400, eudragit NE 30D (ethyl acrelate and methacrylate copolymer dispersion), spectrablend light yellow, carnauba wax, Opacode WB NS-78-17821, iron oxide (E172), isopropyl alcohol, propylene glycol, titanium dioxide (E171) and yellow iron oxide (E172).


How to use Premique?

Premique should be taken at around the same time each day. You can start taking it at any time. If you are switching from a different type of combined continuous HRT or if you’re new to HRT. If you’re switching from a combined cyclical or sequential regime that causes a monthly bleed, you should finish your current pack before starting Primique.

Premique is taken every day of the month and does not produce a monthly bleed.

Premique dosage

The recommended dose of Premique is one tablet per day. Always take the amount prescribed by your doctor. 

Side Effects

Premique side effects

The most common side effect of Primique is breast pain or tenderness, which occurs in over 1 in 10 women.

Other side effects are:

  • Vaginitis (irritation of the vagina or vulva)
  • Depression
  • Joint or muscle pain
  • Changes in vaginal bleeding such as breakthrough bleeding, spotting, painful periods
  • Breast enlargement or discharge
  • Weight changes
  • Changes in the level of triglycerides (fats) in your blood
  • Vaginal infection including thrush
  • Changes in libido (sex drive)
  • Mood changes
  • Headaches and migraines
  • Anxiety
  • Dizziness
  • Blood clots
  • Nausea or vomiting
  • Abdominal pain or bloating
  • Gallbladder conditions
  • Oedema (swelling)
  • Breast changes including fibrocystic change and breast cancer
  • Allergy and anaphylaxis
  • Glucose intolerance
  • Irritability
  • Stroke
  • Heart attack
  • Superficial thrombophlebitis (inflammation of a vein)
  • Exacerbation of asthma
  • Vomiting
  • Pancreatitis
  • Skin discoloration
  • Hirsutism (male pattern hair growth)
  • Itching or rash
  • Changes to uterine fibroids
  • Hypocalcaemia (low calcium)
  • Exacerbation of chorea (a movement disorder)
  • Jaundice (yellow skin)
  • Increase in blood pressure

Taking HRT may also increase your risk of developing breast cancer, endometrial cancer, ovarian cancer, venous thromboembolism (blood clot), stroke and heart disease.

Speak to your doctor if you’re worried about side effects or risks. 


Premique should not be used if you:

  • Have a blood clot or have experienced one in the past
  • Have recently had a heart attack or stroke 
  • Have angina pectoris 
  • Have ever experienced breast cancer or endometrial cancer
  • Experience endometrial hyperplasia 
  • Have undiagnosed abnormal vaginal bleeding
  • Have a condition which increases your risk of having a blood clot
  • Have certain liver conditions
  • Have porphyria 
  • Are pregnant or breastfeeding 
  • Are allergic to any of the ingredients 

Extra care should be taken if you: 

  • Have a family history of breast cancer 
  • You have a condition that increases your risk of blood clots (e.g. obesity, high cholesterol, diabetes)
  • Have a history of benign breast lumps
  • Experience endometriosis 
  • Have fibroids in the womb 
  • Have a family history of blood clots 
  • Have high blood pressure
  • Have problems with your kidneys
  • Have ever experienced gallbladder disease 
  • Suffer from migraines 
  • Have systemic lupus erythematosus
  • Have epilepsy 
  • Have asthma 
  • Have otosclerosis

Drug interactions

Certain medications can interfere with the way Premique works. Tell your doctor if you are taking:

  • Medication for infection e.g. nevirapine, efavirenz, rifampicin, rifabutin
  • Medication for epilepsy e.g. phenobarbital, phenytoin, carbamazepine
  • Metyrapone 
  • Aminoglutethimide
  • St John's wort

Treatment Options

Premique vs. other types of HRT

Premique is a type of low dose combined continuous hormone replacement therapy. Other similar products include Elleste Duet Conti and Kliovance. If you prefer a patch, Evorel delivers hormones via your skin. These products are suited to women who do not regularly menstruate. 

For women still having periods, or who are within a year of having a normal period, cyclical HRT may be more suitable, for example Elleste Duet or Trisequens.

Women who have had a hysterectomy can take oestrogen only supplements such as Elleste Solo, Premarin or Evorel

If your symptoms are confined to the vulva and vagina, you may be more suited to using a vaginal-only therapy such as estriol cream or Vagifem.

Tibolone is another form of hormone therapy, which although doesn’t directly replace deficient hormones, it mimics the activity of the body’s natural hormones and helps to alleviate menopausal symptoms.

Alternatives to HRT

Hormone replacement therapy may not be suitable for everyone but there are alternative options. A medicine called Tibolone works in a similar way to HRT. Rather than containing hormones it breaks down within the body to make substances which mimic your natural hormones. 

Lifestyle changes can also help to ease the symptoms of menopause. Exercising regularly, stopping smoking, cutting down on caffeine and spicy food and staying cool during the night can ease hot flushes. A healthy, balanced diet will help prevent weight gain and maintain the health of the bones. Exercise can also help to manage stress and your mood, alongside giving yourself time to relax and take care of yourself.

Lifestyle changes to improve menopause symptoms

Menopause symptoms can also be managed by making changes to your lifestyle to help your body to manage the discomfort. Keeping active and exercising will benefit your mood and stress levels while also reducing  hot flushes and helping to maintain a healthy weight. Hot flushes can also be reduced by cutting down on caffeine, spicy food and keeping cool during the night. Quitting smoking will also benefit you in this way, while reducing your likelihood of experiencing a heart attack, stroke or cancer. Taking up activities like yoga or meditation can help you to manage stress and be able to relax.


Can Premique cause depression?

Depression or changes to your mood is a potential side effect of Premique. This is because oestrogen can have an effect on your mood, particularly during times when your hormone levels are fluctuating. Signs of depression include feeling low, having negative thoughts, feeling lethargic and lacking in energy, losing interest in things and having trouble sleeping. If you experience this then see your doctor for advice on how to cope. 

Is Premique suitable for vegans?

Premique contains conjugated oestrogens, some of which are obtained from the urine of pregnant female horses which are typically bred for this purpose. While it doesn’t contain any meat or tissue from animals, some people who follow a vegan or vegetarian diet may wish to use an alternative form of HRT which does not contain equine products such as Elleste Duet Conti or Kliovance.

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