Reviewed by Dr Samantha Miller MB ChB
(2017, University of Glasgow)
GMC number: 7561464
Information last reviewed 25/08/2021
Seretide is a combination inhaler used to manage and control asthma. As a preventer inhaler, it is used daily to stop symptoms from flaring up and causing an asthma attack. It combines corticosteroids with a bronchodilator to both soothe inflammation and open the airways.
Seretide needs to be used daily to keep your asthma under control. It prevents your symptoms from flaring up or leading to an asthma attack, allowing you to breathe more easily and to depend less on your reliever inhaler. You need to keep using it, even if you feel better. If you stop using it, your symptoms may start to get worse.
Seretide cannot be used to treat an asthma attack. Only your blue reliever inhaler should be used in the event of an asthma attack. Seretide is for prevention only and cannot relieve symptoms after they have occurred.
Dose |
Accuhaler - one puff, once per day Evohaler - two puffs, twice per day |
Type of Medicine | Combination inhaler with corticosteroid and long-acting bronchodilator (LABA) |
Mechanism |
Triggers beta-2 receptors, allowing smooth muscles in the lungs to relax, allowing better airflow. Also acts on corticosteroid receptors, providing anti-inflammatory action |
Available Strengths |
50mcg, 100mcg, 125mcg, 250mcg or 500mcg |
Active Ingredient |
Fluticasone propionate, salmeterol xinafoate |
Price |
From £39.25 |
Side Effects |
Can include headache, increased number of colds, thrush in the mouth and throat, muscle cramps, pain in the muscles and joints |
The active ingredients in Seretide are salmeterol (as salmeterol xinafoate) and fluticasone propionate.
Seretide Evohalers also contain the propellant norflurane (HFA 134a).
Seretide Accuhalers also contain lactose monohydrate (which contains milk proteins)
There are no known common ingredients or inactive ingredients in Seretide that are known to cause a severe allergic reaction in users. However, if you know you are allergic to any of the active or inactive ingredients please let your doctor know. Make sure to get emergency medical treatment if you experience trouble breathing, a skin rash or itchiness after taking this medication.
The standard dosage of Seretide is 1–2 puffs twice a day. Always follow the prescribing doctor’s instructions when taking Seretide.
Start taking Seretide as soon as you have been prescribed the inhaler. It's usually taken once in the morning and once in the evening. Seretide is often prescribed for people whose asthma has gotten worse or if one type of preventer medicine has not proved effective for keeping it under control.
Before using your Seretide Evohaler for the first time, test it by taking the cap off, shaking the canister and pressing down on the button to release a puff into the air.
When you’re ready, shake the inhaler and sit or stand upright. Seal your lips around the mouth of the inhaler and start to breathe in. At the same time, press down once on the canister to release the medication, and keep breathing in as long as comfortable. Hold your breath for a few seconds, if comfortable, before breathing out again. If you need to take a second puff, wait 30 seconds and then repeat the process.
Seretide Accuhaler is a dry powder inhaler. Before each use, open the outer case to reveal the mouthpiece. Then slide the plastic lever all the way back. This releases the medication ready to be inhaled. When you are ready, breathe out fully before sealing your lips around the mouthpiece. Breathe in slowly and deeply, holding your breath for up to ten seconds before exhaling. Repeat these steps if you need to take two puffs.
You should not stop taking Seretide unless your doctor advises you to do so. Seretide must be taken daily as prescribed. It is a long term form of treatment, and your doctor will regularly review your condition to ensure the inhaler is working correctly. If you experience troublesome side effects, speak to your doctor before stopping Seretide.
Using more Seretide than you should have is unlikely to be harmful, but you should inform your doctor or pharmacist. Keep using your Seretide inhaler exactly as your doctor has prescribed. If your symptoms are not controlled, speak to your doctor rather than increasing the dose yourself.
If you have forgotten a dose of Seretide, then take it as soon as you can unless it's nearly time for your next one. You should never take double the dose to make up for a missed one.
Common side effects include:
Uncommon side effects may include:
Rare side effects may include:
Patients with COPD may experience:
If you experience troublesome side effects, speak to your doctor.
Seretide is not suitable for anyone who is allergic to the ingredients or for children under four.
Inform your doctor if you have any of the following conditions:
Always inform your doctor if you are taking any other medications to ensure that the combination is safe. In particular, if you are taking:
Rinsing out your mouth after using your inhaler will help prevent fungi from building up and causing thrush. In addition, it can help to brush your teeth or use mouthwash regularly. Always use your inhaler as instructed, and make sure you read the instructions carefully before starting.
Seretide and Symbicort are both combination inhalers that work in similar ways to reduce inflammation in the lungs and to relax and widen the airways to breathe easier. Seretide contains fluticasone and salmeterol, whereas Symbicort contains budesonide and formoterol.
The Seretide Evohaler is a metered-dose inhaler (MDI) which releases the medicine in the form of a spray or mist when the user presses down on the top of the canister. It can feel trickier to use as you must press down on the canister and breathe in simultaneously. The medicine contained in the Accuhaler is a dry powder, each dose being released before you breathe it in. This model may be more suitable for children and teenagers as it does not require two actions at once.
Seretide is a combination inhaler which means it has a more substantial effect than single medicine inhalers. It can help to manage more severe asthma, as well as COPD. However, as a preventer inhaler, it cannot be used to treat an asthma attack, so it's essential to have your reliever inhaler to hand in case you need it.
Seretide may produce an unpleasant taste if the medicine hits the back of the throat or mouth instead of going directly into the lungs. This is a sign you are not using your inhaler correctly. If you struggle to use your inhaler, speak with your doctor who may recommend a different inhaler, or may provide you with a spacer to use with the inhaler.
Seretide may also be prescribed to treat chronic obstructive pulmonary disease (COPD).
Prices from:
Reliever inhaler
Reliever inhaler
Preventer (steroid) inhaler
Preventer (steroid) inhaler
Preventer (steroid) inhaler
Preventer (steroid) inhaler
Combination inhaler
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