Buy Spedra tablets (avanafil) to try a new effective ED treatment

  • New erectile dysfunction treatment that works in as little as 15 minutes
  • Our doctors can issue a prescription once you have taken a short, 2 minute online assessment
  • Delivered to your door in plain, discreet packaging
  • Available from £20.99 + prescription fees and delivery costs

Our prices

Strength Quantity Price Stock
50mg4 tablets£20.99In Stock
50mg8 tablets£32.99In Stock
50mg12 tablets£64.99In Stock
50mg16 tablets£59.99In Stock
50mg24 tablets£116.99In Stock
50mg32 tablets£152.99In Stock
100mg4 tablets£24.99In Stock
100mg8 tablets£48.99In Stock
100mg12 tablets£79.99In Stock
100mg16 tablets£94.99In Stock
100mg24 tablets£134.99In Stock
100mg32 tablets£179.99In Stock
200mg4 tablets£33.99In Stock
200mg8 tablets£54.99In Stock
200mg12 tablets£94.49In Stock
200mg16 tablets£107.99In Stock
200mg24 tablets£179.99In Stock
200mg32 tablets£242.99In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

Safe and discreet

  • Safe and regulated treatments
  • 100% discreet and confidential
  • UK qualified doctors
  • Fully registered UK pharmacy


Dr Samantha Miller

Reviewed by Dr Samantha Miller MB ChB
(2017, University of Glasgow)
GMC number: 7561464

Information last reviewed 23/05/2021


What is Spedra?

Spedra (avanafil) is a prescription medicine used to treat erectile dysfunction. It is a relatively new, fast-acting treatment that works in combination with sexual stimulation to help men achieve and maintain an erection for long enough to engage in sexual activity.

How does Spedra work?

Spedra contains the active ingredient avanafil. Avanafil is a type of drug known as a PDE-5 inhibitor. This means that it works by relaxing blood vessels and increasing blood flow to the penis. During sexual stimulation, Spedra helps a man achieve and maintain an erection.

How effective is Spedra?

Spedra is proven to be an effective treatment for ED in the majority of users. Data from clinical studies showed that 58% of men who tried to have sex after taking 100mg of Spedra were successfully able to.

What makes Spedra work so quickly?

Spedra (avanafil) has a faster absorption rate than other PDE-5 inhibitors, such as Viagra (sildenafil), Levitra (vardenafil) and Cialis (tadalafil). It can become effective in just 15 minutes reaching maximum effect within 30–45 minutes. However, Spedra is absorbed more slowly if consumed with a fatty meal, so the effects could be slightly delayed.

Spedra and psychological ED

Often, ED has a psychological cause, such as anxiety or depression. In these cases, counselling can be an effective treatment. This approach can take time and Spedra may be recommended for use in the short term, although it is important not to allow treatment to mask the problem.

Spedra summary


No more than 1 tablet, once per day, at least 15 minutes before sexual activity

Type of Medicine

PDE5 inhibitor


Blocks the action of PDE5, which allows blood vessels around the penis to relax and allow greater blood flow

Available Size

4, 8, 12 16, 24 or 32 tablets

Available Strengths

50mg, 100mg or 200mg

Active Ingredient



From £4.78 per tablet

Side Effects

Can include headache, flushing, nasal congestion, feeling dizzy, sleepy or tired, back pain, palpitations, indigestion, blurred vision, raised liver enzyme levels


Active ingredient

The active ingredient in Spedra is avanafil.

Inactive ingredients

The inactive ingredients in Spedra are mannitol, fumaric acid, hydroxypropyl cellulose, hydroxypropyl cellulose low substituted, calcium carbonate, magnesium stearate and yellow iron oxide (E172).


Starting Spedra

Spedra can be started at any convenient time. It may take a while for your body to adjust and for the effects of Spedra to take effect. You are recommended to trial Spedra several times over the course of a few weeks to find out if it’s effective for you. If you experience some effect from Spedra, but the effect is not enough for sex, speak to your doctor about increasing your dose.

How to take Spedra

Swallow one Spedra tablet with water approximately 15 to 30 minutes before sexual activity, or at least 30 minutes before sexual activity if you are taking a 50mg dose. If taken with food, particularly a heavy or fatty meal, Spedra can take longer to become effective. Spedra only works in combination with sexual stimulation. Do not take more Spedra than you should, as this will increase the risk of side effects and will not increase its effectiveness.

Spedra dosage

The recommended starting dose of Spedra is 100mg no more than once per day. This can be reduced to 50mg or increased to 200mg by a doctor if you feel that your dose is too strong or too weak.

How to get an erection whilst taking Spedra

Spedra should be taken between 15 and 30 minutes before engaging in sexual activity to be effective. When you become aroused, Spedra will aid your ability to achieve and maintain an erection.

Side Effects

Spedra side effects

Like all medications, Spedra can cause side effects in some patients. If you experience any of the following rare but serious side effects, stop taking Spedra and seek immediate medical help:

  • A prolonged and possibly painful erection lasting more than 4 hours (priapism)
  • Blurred vision
  • Sudden decrease or loss of vision or hearing

Up to 1 in 10 people may experience headaches, flushing or nasal congestion while taking Spedra. 

Less common side effects, affecting up to 1 in 100 people, include:

  • Feeling dizzy
  • Feeling sleepy or tired
  • Sinus congestion
  • Back pain
  • Hot flushes
  • Breathlessness
  • Palpitations or racing heartbeat
  • Indigestion
  • Blurred vision
  • Raised liver enzymes

Rarely (1 in 1,000 cases) the following side effects may occur:

  • Influenza
  • Flu-like illness
  • Stuffy or runny nose
  • Hayfever
  • Congestion in the nose, sinuses or upper part of the airway
  • Gout
  • Sleeping difficulties
  • Premature ejaculation
  • Feeling strange
  • Restlessness
  • Chest pain
  • Serious chest pain
  • Fast heartbeat
  • High blood pressure
  • Dry mouth
  • Stomach ache or heartburn
  • Pain or discomfort in the lower abdomen
  • Diarrhoea
  • Rash
  • Pain in the lower back or side of the lower chest
  • Muscle aches or pain
  • Muscle spasm
  • Frequent urination
  • Penile disorder
  • Spontaneous erection without sexual stimulation
  • Itching in the genital area
  • Feeling weak and/or tired
  • Swelling in the ankles or feet
  • Increased blood pressure
  • Blood in the urine
  • Abnormal sound from the heart
  • Abnormal blood test result for a prostate test called ‘PSA’
  • Abnormal blood test result for bilirubin, a chemical produced from the normal breakdown of red blood cells
  • Abnormal blood test result for creatine, a measure of kidney function
  • Fever
  • Nosebleeds


Do NOT take Spedra if you:

  • Are allergic to avanafil or to any of the other ingredients in this medication
  • Have a serious cardiac problem
  • Have had a stroke, heart attack or life-threatening arrhythmia in the last 6 months
  • Have uncontrolled low or high blood pressure
  • Have angina or chest pain during sex or other physical activity
  • Have a serious liver or kidney problem
  • Have loss of vision in one eye due to not enough blood getting to your eye (NAION)
  • Have a family history of serious eye problems

Take particular care with Spedra and inform your doctor if you:

  • Have heart trouble
  • Experience prolonged erections lasting for 4 hours or more
  • Have a physical condition affecting the shape of your penis
  • Have a bleeding disorder or active peptic ulceration

Drug interactions

Do NOT take Spedra in combination with:

  • Nitrates such as amyl nitrate, glyceryl trinitrate (GTN) or “poppers”
  • Medicines for HIV infection, including ritonavir, indinavir, saquinavir, nelfinavir or atazanavir
  • Antifungal medications including ketoconazole, itraconazole or voriconazole
  • Certain antibiotics such as clarithromycin and telithromycin
  • Riociguat

Tell your doctor or pharmacist if you are taking any other medications, including those purchased over the counter without a prescription. In particular, tell your doctor if you are taking:

  • Alpha-blockers
  • Medicines for arrhythmia, such as quinidine, procainamide, amiodarone or sotalol
  • Phenobarbital or primidone for epilepsy
  • Carbamazepine
  • Moderate CYP3A4 inhibitors, including, amprenavir, aprepitant, fluconazole, fosamprenavir and verapamil

Spedra and alcohol

Some patients report feeling dizzy when taking this medication and it is recommended to limit your alcohol intake in this event. Drinking alcohol can also inhibit your ability to get an erection and prevent you from experiencing the full effects of Spedra.

Spedra and heavy machinery/driving

Spedra can cause dizziness and disturbances to vision. If you experience either of these side effects, avoid driving or operating heavy machinery.

Treatment Options

Lifestyle changes to improve ED

The root cause of ED is often psychological. Finding ways to reduce stress in your life can be extremely beneficial, as can maintaining a healthy lifestyle and exercising regularly. Anxiety may also contribute and can be further exacerbated by difficulties with sexual performance. Being open with your partner about your anxieties can help you to relax and improve your sexual performance. For advice on dealing with anxiety or depression, speak to a doctor or nurse.

Spedra vs. other ED medications

Spedra is the most recent prescription treatment for ED and stands out for its short activation time of just 15 minutes. The first and most popular treatment for ED is Viagra (sildenafil), which was approved in 1998. Since then, other PDE-5 inhibitors have been developed, including Cialis (tadalafil) and Levitra (vardenafil). Viagra and Levitra can remain effective from up to 5 hours, while Cialis remains active for up to 36 hours.

Why doesn’t Spedra work for me?

Different ED treatments are better suited to different people, and it is not uncommon to try a few different treatments to begin with. If Spedra does not work for you, speak to a doctor about alternative treatments for erectile dysfunction.


Is Spedra a cure?

Spedra is not a cure for ED, but it can help you achieve and maintain an erection. The underlying cause, whether it is physical or psychological will not be treated by taking Spedra. In ED with a psychological cause, Spedra can help to relieve some of the stress and worry associated with performance issues in the short term.

Will Spedra give me an erection for hours?

Spedra only works in combination with sexual stimulation, helping a man achieve and maintain an erection when he is aroused. A very rare side effect of Spedra is a prolonged and sometimes painful erection. If you experience this, stop taking Spedra and seek immediate medical care.

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