Reviewed by Virginia Chachati MPharm
(2013, University College London)
GPhC Registration number: 2087654
Information last reviewed 10/06/2021
Tetralysal is an antibiotic used to treat acne and other bacterial infections. It comes in a capsule that you swallow, typically once a day.
Tetralysal works by targeting bacteria, preventing them from growing and multiplying. The medication is particularly effective against acne as it works against a type of bacteria called Propionebacterium acnes. This is the bacteria which causes acne, feeding on the oils which are produced by the sebaceous glands.
Tetralysal will start to work a week after taking it. You should notice a difference in your skin a couple of weeks after taking Tetralysal daily.
The active ingredient in Tetralysal is lymecycline, which is an antibiotic.
Acne is a condition where spots, pimples and blackheads appear on your skin. You can experience acne at any age, though it often starts in childhood. When the pores in your skin become blocked with excess oil and dead skin cells, you may experience acne. There are many underlying causes of acne. These include hormonal changes, the menstrual cycle, pregnancy and menopause.
Dose |
One capsule, once per day in the morning |
Type of Medicine |
Antibiotic |
Mechanism |
Blocks bacterial synthesis of important proteins for reproduction |
Available Size |
56 or 84 capsules |
Available Strengths |
408mg |
Active Ingredient |
Lymecycline |
Price |
From 48p per capsule |
Side Effects |
Can include jaundice, nausea, vomiting, hypersensitivity, blistering or peeling of the skin, feeling dizzy, headaches, ulcers, itchiness |
Tetralysal contains lymecycline, which can occasionally cause allergic reactions, such as a skin rash. If you experience this or any signs of a serious allergic reaction after taking the medication get immediate medical help and speak with a doctor as soon as possible. Signs of a serious allergic reaction as the development of hives, facial or lip swelling, difficulty breathing, chest tightness or dizziness.
The active ingredient in Tetralysal is lymecycline.
The inactive ingredients in Tetralysal are magnesium stearate and colloidal hydrated silica. The outer capsule is made from gelatin, titanium dioxide (E171), erythrosine (E127), quinine yellow (E104) and indigotine (E132).
The standard dose of Tetralysal to treat acne is one capsule, or 300 mg, per day. Always take Tetralysal as your doctor or pharmacist has prescribed.
Tetralysal should be taken once a day in the morning. Swallow the capsule whole with a glass of water. You can take Tetralysal with a small amount of food to avoid feeling sick.
Take Tetralysal for as long as your doctor has prescribed. To treat acne, this is usually eight weeks. Always complete the treatment course, even if your acne clears up. Otherwise your acne symptoms might return.
If you take too much Tetralysal it is unlikely to cause you harm. Speak to your doctor or healthcare professional for advice as soon as possible.
If you forget to take Tetralysal, take your missed dose as soon as you remember, unless it's nearly time for your next one. Do not take two capsules at the same time to make up for a missed dose.
Possible side effects of Tetralysal include:
Signs of an allergic reaction to Tetralysal include:
If you experience any of the symptoms above, seek immediate emergency medical attention.
Do not take Tetralysal if:
Let your doctor know, before you take Tetralysal, if you have:
The following medicines can affect how Tetralysal works. Wait at least two hours after taking Tetralysal before using:
Avoid the following medicines while taking Tetralysal:
Tetralysal is not safe to take during pregnancy or while breastfeeding. Speak to your doctor if you are pregnant, or trying to get pregnant, for further advice before using Tetralysal.
You can drink alcohol while taking Tetralysal.
Tetralysal will not affect the contraceptive pill or emergency contraceptives. If Tetralysal causes diarrhoea whilst you are taking contraceptive pills, speak to your doctor for advice.
Current research has shown that Tetralysal does not affect fertility in either men or women.
Tetralysal can build up in teeth and bones that are still growing, which can lead to permanent staining. This is why Tetralysal is not suitable for children under 12 years old or pregnant women. Tetralysal is unlikely to stain adult teeth.
Thrush is a possible side effect while taking Tetralysal. This is because Tetralysal is a broad spectrum antibiotic, so it can kill some of the protective bacteria you normally have on your body. When this happens, an overgrowth of fungus can occur that leads to a yeast infection, commonly known as thrush.
There are alternative treatment options available for acne. You will usually start with over the counter remedies from a pharmacy. If these do not help treat your acne, you can see a doctor to get prescription only medicines. They may prescribe antibiotics, retinoids, azelaic acid or benzoyl peroxide. In addition, the combined oral contraceptive pill can help manage acne in women.
There are ways to treat acne at home to reduce inflammation and help spots to heal. Some popular substances include:
These home remedies are likely to work well for mild acne and the occasional pimple but moderate to severe acne will need prescription medicine to treat it effectively. Avoid using toothpaste to dry out spots as this can irritate the skin.
There are lifestyle changes you can make to help manage acne and prevent further breakouts. For example:
Tetralysal is only available on prescription from a doctor and cannot be purchased over the counter at a pharmacy.
Tetralysal is the brand name for the antibiotic lymecycline. It is designed to target bacteria which cause acne, making it more effective than other antibiotics in treating the skin condition. Other antibiotics are used to treat different types of infections.
There are six different types of spots associated with acne:
Severe acne usually consists of cysts and nodules. These types of spots are most likely to result in permanent scarring.
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