Order Tibolone to treat menopausal symptoms

Tibolone is a hormone replacement therapy that can treat the symptoms of menopause in women, including hot flushes, mood swings, reduced libido, discomfort during sex, and vaginal irritation.

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2.5mg84 tablets£39.95In Stock
Prices exclude a prescription fee. This treatment requires a quick online consultation,
which a doctor will review to determine if a prescription is appropriate.

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What is tibolone?

Tibolone is a type of hormone replacement therapy (HRT) which is used to treat the symptoms of menopause in women, including hot flushes, mood swings, reduced libido, pain or discomfort during sex, and vaginal irritation, inflammation or dryness. tibolone may also be prescribed to prevent the onset of osteoporosis in women who are unable to take other forms of HRT.

Tibolone is a synthetic steroid molecule which when broken down in the body, has the same kind of effects as oestrogen, progesterone and androgens. It therefore helps to mediate the effects of menopause which are caused by deficiency in these hormones.

How does tibolone work?

During menopause, the amount of oestrogen produced by the ovaries decreases, resulting in symptoms such as mood swings, reduced libido, pain or discomfort during sex, vaginal irritation and dryness. Tibolone is a synthetic steroid which mimics the activity of the female sex hormones oestrogen and progesterone, and of the androgen hormone testosterone. When absorbed, tibolone is broken down into three compounds which act similarly to the body’s natural oestrogen, progesterone and testosterone, restoring the body’s hormonal balance and relieving the symptoms of menopause.


Active ingredients

The active ingredient in tibolone is 2.5mg of tibolone.

Inactive ingredients

The inactive ingredients in tibolone are potato starch, lactose monohydrate, mannitol, potato starch, magnesium stearate and ascorbyl palmitate.


The recommended dose of tibolone is 1 x 2.5mg tablet taken once daily at the same time each day.

How to start tibolone?

You should only start taking tibolone following consultation with a doctor. You can start taking it straight away if:

  • You are changing from a period-free HRT
  • You have never used HRT before
  • It was prescribed to you following a hysterectomy
  • You are being treated for endometriosis

If you are changing over from a type of HRT which allows for monthly withdrawal bleeds (such as Elleste Duet or Evorel Sequi), you should complete your pack before starting tibolone.

You should NOT take tibolone if you have experienced a natural period within the last 12 months.

How to take tibolone?

Always take tibolone as instructed by a doctor. Swallow each tablet with water, without chewing or breaking it, at the same time each day. To help you remember, try and make this a part of your daily routine - for example, take your tablet with breakfast each day, or when you brush your teeth in the morning or evening. Each strip of tablets is marked with the days of the week to help you keep track. When you finish a strip, start a new one on the next day without leaving a gap.
If you forget to take a tablet, try and take it within 12 hours of the normal time. If 12 hours have already passed, just skip the dose and take the next tablet at the normal time. Never take a double dose to make up for a missed one.

Side Effects

Like all medications, tibolone can cause side effects in some patients. If you experience any of the following, stop taking tibolone immediately and see a doctor straight away:

  • A significant rise in blood pressure, which may manifest as a severe headache or blurred vision
  • Jaundice (yellowing of the skin or whites of the eyes)
  • Sudden migraines 
  • Signs of a blood clot e.g. leg pain, chest pain

 Common side effects, which can affect up to 1 in 10 people, include:

  • Breast pain
  • Stomach or pelvic pain
  • Unusual hair growth
  • Vaginal bleeding or spotting (this is common in the first few months of using HRT and usually stops over time)
  • Thrush
  • Thickening of the lining of the womb or the lining of the cervix
  • Change in vaginal discharge
  • Vulvovaginitis (irritation of the vulva or vagina)
  • Weight gain
  • Abnormal smear test results (but not due to cancer)

 Uncommon side effects (affecting up to 1 in 100 women) can include:

  • Signs of fluid retention (swelling of the hands, ankles or feet)
  • Stomach upset
  • Acne
  • Painful nipples
  • Vaginal infection

 Rarely, women taking tibolone may experience itchy skin. The following have also been reported by women taking Livial:

  • Depression, headaches, dizziness
  • Joint or muscle pain
  • Rash or itching of the skin
  • Loss of vision or blurred vision
  • Changes in liver tests

 Tibolone slightly increases the risk of developing breast cancer or endometrial cancer. It is important to go for regular health checks (breast screening and cervical smear tests) while taking this medication. Speak to your doctor for more information if you are worried.


Do NOT take tibolone if you:

  • Are allergic to any of the ingredients in this medication
  • Have, have ever had, or are suspected of having breast cancer
  • Have a form of oestrogen-sensitive cancer
  • Have unexplained vaginal bleeding
  • Have endometrial hyperplasia (excessive thickening of the womb lining)
  • Have or have ever had thrombosis (blood clot in a vein)
  • Have a blood clotting disorder
  • Have or have recently had a heart attack, angina, or any other disease caused by a blood clot in an artery
  • Have or have ever had a liver disease
  • Have porphyria 
  • Are pregnant or think you  might be pregnant
  • Are breastfeeding

 You should tell your doctor before taking tibolone if you have ever experienced any of the following:

  • Fibroids inside the womb
  • Endometriosis (growth of the womb lining outside of the womb) or endometrial hyperplasia (excessive growth of the womb lining)
  • Increased risk of developing blood clots (e.g. obesity, major surgery, high cholesterol)
  • Increased risk of developing an oestrogen-sensitive cancer (e.g. a family history of cancer)
  • High blood pressure
  • A liver disorder
  • Diabetes
  • Gallstones
  • Migraines or severe headaches
  • Systemic lupus erythematosus (a disease of the immune system affecting many organs of the body)
  • Epilepsy
  • Asthma
  • Otosclerosis (a disease affecting the eardrum and hearing)

Drug Interactions

Before taking tibolone, tell your doctor or pharmacist if you are taking any other medications, including those purchased over the counter without a prescription. The following medications may interfere with the effect of tibolone:

  • Medicines for blood clotting, such as warfarin
  • Medicines for epilepsy, such as phenobarbital, phenytoin and carbamazepine
  • Medicines for tuberculosis, such as rifampicin
  • Herbal remedies containing St John’s Wort

Pregnancy and breastfeeding

Do not take Tibolone if you are breastfeeding, pregnant, think you might be pregnant, or are planning on becoming pregnant. If you become pregnant while taking Tibolone, stop taking it immediately and consult a doctor.

Treatment Options

Other forms of HRT

While tibolone, brand name Livial, is a synthetic steroid, other forms of HRT contain forms of the hormones oestrogen and/or progesterone themselves. Tibolone is thought to carry a slightly lower risk of breast cancer than hormonal HRTs, but you can speak to your doctor to work out which option is best for you.

Tibolone is designed to be taken by women who have finished having menstrual periods, i.e. have not had a natural period in over 12 months. Other alternative forms of HRT for this group of women include Elleste Duet Conti, Kliovance (both taken as a tablet) and Evorel Conti (used as a patch).

If you’re still having periods, or had your last period within the past year, you’d be most suited to a combined cyclical HRT, which allows for a regular and predictable monthly bleed – examples include Elleste Duet, Trisequens and Evorel Sequi.

Oestrogen-only HRTs can be taken orally, applied to the skin as a transdermal patch, or applied topically as a gel or cream. They should only be used by women who have had a hysterectomy, or who have an alternative progesterone supplement such as a Mirena intrauterine system (IUS), as progesterone is required to prevent a dangerous build up of the uterine lining. Premarin and Elleste Solo are oestrogen-only HRTs that can be taken orally, while Elleste Solo MX80, Elleste Solo MX40 and Evorel are transdermal patches which are changed twice weekly. 

Patches have the benefit of bypassing the digestive system, reducing the likelihood of developing side effects. 
If you are in the early days of your menopause and are suffering from only vaginal symptoms such as dryness, irritation, inflammation, pain or discomfort during sex, spotting, and recurrent UTIs, you may wish to try a topical form of HRT. Ovestin or estriol creams, and vaginal suppositories such as Vagifem contain an oestrogen supplement and work locally in the vaginal region to relieve these symptoms. They are also less likely to cause side effects, but bear in mind that they can have a weakening effect on latex condoms and diaphragms.

Alternatives to HRT

Although HRT is the most popular and accessible treatment for the symptoms of menopause, some women choose to try herbal supplements to help with hot flushes and mood swings. However, the effectiveness of herbal supplements is unknown, so you should make sure to consult a doctor or pharmacist for advice and information before trying a product.

Lifestyle changes to improve menopause symptoms

Making a few lifestyle changes can help you to deal with the symptoms of menopause. To reduce the impact of hot flushes and night sweats, try cutting down on caffeine, alcohol and spicy foods, and quit smoking if you haven’t already done so. Meanwhile, exercising regularly and increasing your intake of vitamin D, which is vital for the production of calcium, can help to keep your bones strong and healthy. Although there is little evidence to suggest that eating an oestrogen-rich diet will significantly reduce symptoms of menopause, some women choose to increase their intake of plant-based foods containing oestrogen, such as sesame and flaxseed, died fruits, oranges, strawberries and apricots.


Is tibolone safe?

Tibolone is considered a safe and effective first-line treatment for the symptoms of menopause, and a second-line treatment for preventing the onset of osteoporosis. HRT in general carries a slight increase in the risk of developing oestrogen sensitive cancers, such as breast cancer, ovarian cancer and endometrial cancer, stroke, and blood clots, but for most women, the benefits of HRT outweigh this risk. Make sure to read the patient information carefully and inform your doctor of any previous or existing conditions you have.

Will I have to use HRT forever?

Many women continue to use HRT for several years. However, the potential health risks associated with HRT do increase slightly with time and age, so a doctor will usually prescribe the lowest dose necessary for the patient’s symptoms and for the shortest amount of time. While HRT delays the onset of osteoporosis, it does not prevent it altogether. Deciding when to come off of HRT is a personal decision that should be discussed with a doctor beforehand.

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